Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616621 | 0.92 | SMN1; SMN2 (0.40) | RAB9ANPC1SMN1; SMN2KMT2AKDM4C | |
| SCHEMBL6618882 | 0.90 | ALDH1A1 (0.40) | RAB9ANPC1SMN1; SMN2KMT2AKDM4C | |
| SCHEMBL6616778 | 0.89 | JAK2 (0.41) | RAB9ANPC1SMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL6621561 | 0.88 | SMN1; SMN2 (0.40) | RAB9ANPC1SMN1; SMN2KMT2AKDM4C | |
| SCHEMBL6615757 | 0.88 | KDM4C (0.40) | RAB9ANPC1SMN1; SMN2KMT2AKDM4C | |
| SCHEMBL6614350 | 0.88 | ALDH1A1 (0.41) | RAB9ANPC1SMN1; SMN2KMT2AKDM4C | |
| SCHEMBL6603917 | 0.88 | CHRNA7 (0.36) | RAB9ANPC1SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL6661397 | 0.87 | CRACR2A (0.45) | SMN1; SMN2KMT2AKDM4CCRACR2AALDH1A1 | |
| SCHEMBL6618475 | 0.87 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2KMT2AKDM4C | |
| SCHEMBL6616682 | 0.86 | NAMPT (0.42) | RAB9ANPC1SMN1; SMN2KMT2ACRACR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |