SCHEMBL6604320

SCHEMBL6604320

CCOC(=O)c1nc2cc(F)ccc2[nH]c1=O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.48
BRD4 O60885 3/20 0.45
ADORA3 P0DMS8 3/20 0.43
KDM4E B2RXH2 5/20 0.43
SMN1; SMN2 Q16637 4/20 0.43
KMT2A Q03164 3/20 0.43
ALDH1A1 P00352 6/20 0.43
HPGD P15428 4/20 0.43
GABRA2 P47869 2/20 0.43
GABRB2 P47870 2/20 0.43
GAA P10253 2/20 0.43
HSD17B10 Q99714 3/20 0.42
RAB9A P51151 2/20 0.42
MEN1 O00255 1/20 0.42
GABRP O00591 1/20 0.42
GABRD O14764 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2D6 P10635 1/20 0.42
GABRA1 P14867 1/20 0.42
GABRB1 P18505 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6375213 0.87 ALDH1A1 (0.53) TSHRADORA3KDM4ESMN1; SMN2KMT2A
SCHEMBL6602730 0.85 ALDH1A1 (0.49) ADORA3KDM4ESMN1; SMN2KMT2AALDH1A1
SCHEMBL9704059 0.85 ADORA3 (0.55) ADORA3KMT2AALDH1A1HPGDCYP1A2
SCHEMBL30623229 0.85 ADORA3 (0.55) ADORA3KMT2AALDH1A1HPGDCYP1A2
SCHEMBL9704461 0.84 LMNA (0.43) ADORA3KDM4EALDH1A1HPGDGABRA2
SCHEMBL9705656 0.84 KDM4E (0.50) ADORA3KDM4EKMT2AALDH1A1HPGD
SCHEMBL9705717 0.82 SIRT2 (0.44) ADORA3KDM4ESMN1; SMN2ALDH1A1HPGD
SCHEMBL6705309 0.81 ALDH1A1 (0.46) KDM4ESMN1; SMN2KMT2AALDH1A1HPGD
SCHEMBL880365 0.81 ALDH1A1 (0.62) ADORA3KDM4ESMN1; SMN2KMT2AALDH1A1
SCHEMBL11371536 0.81 MAPT (0.48) SMN1; SMN2KMT2AALDH1A1GAARAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1020453-B1 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERIVATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH KYORIN SEIYAKU KK (JP) 2004-05-19 EP disclosed
US-6348461-B1 CENTRAL NERVOUS SYSTEM ANTAGONIST WITH HETEROCYCLIC SUBSTITUENTS KYORIN PHARMACEUTICAL CO., LTD. (JP) 2002-02-19 US disclosed
EP-1020453-A1 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERI VATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH KYORIN PHARMACEUTICAL CO., LTD. (JP) 2000-07-19 EP disclosed
WO-1992011245-A1 2-ACYLAMIDO DERIVATIVES OF 3,4-DIHYDRO-3-OXO-QUINOXALINE HAVING PHARMACEUTICAL ACTIVITY WARNER-LAMBERT COMPANY (US) 1992-07-09 WO disclosed