Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 8/20 | 0.49 |
| ▸ | PREP | P48147 | 2/20 | 0.43 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6531013 | 0.88 | MMP1 (0.43) | KLK5ALDH1A1MAPTDPP4DPP8 | |
| SCHEMBL6787227 | 0.87 | FKBP1A (0.64) | FKBP1APREPKLK5 | |
| SCHEMBL1997241 | 0.87 | FKBP1A (0.64) | FKBP1APREPKLK5 | |
| SCHEMBL1997238 | 0.87 | FKBP1A (0.64) | FKBP1APREPKLK5 | |
| SCHEMBL6603737 | 0.82 | DPP4 (0.47) | FKBP1APREPDPP4DPP8DPP7 | |
| SCHEMBL7454452 | 0.80 | DPP8 (0.44) | FKBP1AALDH1A1MAPTDPP4DPP8 | |
| SCHEMBL6601649 | 0.79 | DPP8 (0.45) | FKBP1AALDH1A1DPP4DPP8DPP7 | |
| SCHEMBL6606642 | 0.79 | DPP8 (0.45) | FKBP1AALDH1A1DPP4DPP8DPP7 | |
| SCHEMBL7295710 | 0.79 | PREP (0.62) | FKBP1APREPKLK5ALDH1A1TSHR | |
| SCHEMBL11438917 | 0.78 | CMA1 (0.53) | KLK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0924210-B1 | 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives | WYETH K K (JP) | 2004-08-18 | — | — | EP | disclosed |
| EP-0632039-B1 | 2-[1-(1,3-Thiazolin-2-yl)azetidin-3-yl]thio-carbapenem derivatives | WYETH LEDERLE JAPAN LTD (JP) | 2002-01-30 | — | — | EP | disclosed |
| EP-0924210-A1 | 2-(1-(1,3-Thiazolin-2-yl)azetidin-3-yl)thio-carbapenem derivatives | LEDERLE (JAPAN), Ltd. (JP) | 1999-06-23 | — | — | EP | disclosed |
| US-5783703-A | CARBAPENEM INTERMEDIATES | LEDERLE (JAPAN), LTD. (JP) | 1998-07-21 | — | — | US | disclosed |
| US-5679790-A | ANTIBIOTICS, BACTERICIDES | LEDERLE (JAPAN), LTD. (JP) | 1997-10-21 | — | — | US | disclosed |
| US-5534510-A | ORALLY ADMINISTRABLE THIENAMYCIN ANTIBIOTICS; BETA-LACTAMASE INHIBITORS | LEDERLE (JAPAN), LTD. (JP) | 1996-07-09 | — | — | US | disclosed |