SCHEMBL660558

SCHEMBL660558

CC[C@H](Nc1ccc(C(=O)O)cc1)C(=O)O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 1/20 0.47
ALDH1A1 P00352 4/20 0.46
HCAR3 P49019 2/20 0.44
HCAR2 Q8TDS4 1/20 0.44
TDP1 Q9NUW8 3/20 0.44
SMN1; SMN2 Q16637 3/20 0.44
TP53 P04637 2/20 0.44
TSHR P16473 2/20 0.44
HSP90AA1 P07900 1/20 0.44
CYP3A4 P08684 1/20 0.44
THRB P10828 1/20 0.44
ALOX15 P16050 1/20 0.44
CASP1 P29466 1/20 0.44
HIF1A Q16665 1/20 0.44
HSD17B10 Q99714 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
MAPT P10636 2/20 0.42
KDM4E B2RXH2 2/20 0.41
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15697950 1.00 HTT (0.47) HTTALDH1A1HCAR3HCAR2TDP1
SCHEMBL11196579 0.84 ALDH1A1 (0.47) HTTALDH1A1TDP1SMN1; SMN2TP53
SCHEMBL9004065 0.83 CA2 (0.49) ALDH1A1SMN1; SMN2TP53TSHRMAPT
SCHEMBL2878630 0.83 ALDH1A1 (0.50) ALDH1A1TDP1SMN1; SMN2TSHRCYP3A4
SCHEMBL8635820 0.83 ALDH1A1 (0.50) ALDH1A1TDP1SMN1; SMN2TSHRCYP3A4
SCHEMBL4526295 0.83 ALDH1A1 (0.50) ALDH1A1TDP1SMN1; SMN2TSHRCYP3A4
SCHEMBL7358892 0.82 ITGB3 (0.50) ALDH1A1TDP1TP53TSHRMAPT
SCHEMBL7358881 0.82 ITGB3 (0.50) ALDH1A1TDP1TP53TSHRMAPT
SCHEMBL29659890 0.82 KMT2A (0.50) HTTALDH1A1SMN1; SMN2TP53MEN1
SCHEMBL11195208 0.82 HTT (0.45) HTTALDH1A1TDP1SMN1; SMN2TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110263652-A1 Treatment and/or Prevention of Inner Ear Conditions by Modulation of a Metabotropic Glutamate Receptor HOUSE EAR INSTITUTE (US) 2011-10-27 US claimed
EP-2344151-A2 TREATMENT AND/OR PREVENTION OF INNER EAR CONDITIONS BY MODULATION OF A METABOTROPIC GLUTAMATE RECEPTOR HOUSE EAR INSTITUTE (US) 2011-07-20 EP claimed
WO-2010048095-A2 TREATMENT AND/OR PREVENTION OF INNER EAR CONDITIONS BY MODULATION OF A METABOTROPIC GLUTAMATE RECEPTOR HOUSE EAR INSTITUTE (US) 2010-04-29 WO claimed
US-6197820-B1 METABOTROPIC GLUTAMATE RECEPTOR AGONIST/ANTAGONIST (S)-4-CARBOXYPHENYLGLYCINE (S-4CPG), POTENTLY AND SELECTIVELY INHIBITED GLUTAMATE RELEASE FROM GLIOMA CELLS AND THEREBY PREVENTED NEUROTOXICITY, INHIBIT RELEASE OF TOXIC LEVELS OF UAB RESEARCH FOUNDATION 2001-03-06 US claimed
WO-2000062771-A1 USES OF PHENYLGLYCINE DERIVATIVES THE UAB RESEARCH FOUNDATION (US) 2000-10-26 WO claimed
US-11938106-B2 Treatment of tinnitus using glutamate receptor agonists NORTHEAST OHIO MEDICAL UNIVERSITY (US) 2024-03-26 US disclosed
US-20230038631-A1 TREATMENT OF TINNITUS USING GLUTAMATE RECEPTOR AGONISTS NORTHEAST OHIO MEDICAL UNIV (US) 2023-02-09 US disclosed
US-20210251928-A1 TREATMENT OF TINNITUS USING GLUTAMATE RECEPTOR AGONISTS NORTHEAST OHIO MEDICAL UNIVERSITY 2021-08-19 US disclosed
WO-2017142543-A1 TREATMENT OF TINNITUS USING GLUTAMATE RECEPTOR AGONISTS NORTHEAST OHIO MEDICAL UNIVERSITY (US) 2017-08-24 WO disclosed
US-9173864-B2 Treatment and/or prevention of inner ear conditions by modulation of a metabotropic glutamate receptor HOUSE EAR INSTITUTE (US) 2015-11-03 US disclosed
US-20150038464-A1 METHODS OF INCREASING LIGHT RESPONSIVENESS IN A SUBJECT WITH RETINAL DEGENERATION THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (US) 2015-02-05 US disclosed
US-8912203-B2 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders AFRAXIS HOLDINGS, INC. (US) 2014-12-16 US disclosed
EP-1404864-A4 REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS UNIV ROCKEFELLER (US) 2008-05-28 EP disclosed
WO-2007029063-A2 TREATMENT AND/OR PREVENTION OF PERVASIVE DEVELOPMENTAL DISORDERS ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) (CH) 2007-03-15 WO disclosed
US-7129073-B2 Regulation of neuronal function through metabotropic glutamate receptor signaling pathways THE ROCKEFELLER UNIVERSITY (US) 2006-10-31 US disclosed
US-20060223158-A1 REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2006-10-05 US disclosed
EP-1404864-A2 REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS THE ROCKEFELLER UNIVERSITY (US) 2004-04-07 EP disclosed
WO-2002102768-A2 REGULATION OF NEURONAL FUNCTION THROUGH METABOTROPIC GLUTAMATE RECEPTOR SIGNALING PATHWAYS THE ROCKEFELLER UNIVERSITY (US) 2002-12-27 WO disclosed
US-6197820-B1 METABOTROPIC GLUTAMATE RECEPTOR AGONIST/ANTAGONIST (S)-4-CARBOXYPHENYLGLYCINE (S-4CPG), POTENTLY AND SELECTIVELY INHIBITED GLUTAMATE RELEASE FROM GLIOMA CELLS AND THEREBY PREVENTED NEUROTOXICITY, INHIBIT RELEASE OF TOXIC LEVELS OF UAB RESEARCH FOUNDATION 2001-03-06 US disclosed
WO-2000062771-A1 USES OF PHENYLGLYCINE DERIVATIVES THE UAB RESEARCH FOUNDATION (US) 2000-10-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150038464-A1 METHODS OF INCREASING LIGHT RESPONSIVENESS IN A SUBJECT WITH RETINAL DEGENERATION GRM5, GRM1, GRIK5 HTT 2316/4885ALDH1A1 445/4885HCAR3 409/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.