Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765540 | 0.87 | NPC1 (0.37) | NPC1IDO1KDM4EALDH1A1 | |
| SCHEMBL4766646 | 0.81 | CTSK (0.45) | NPC1MEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL4763005 | 0.81 | TAS1R3 (0.48) | NPC1 | |
| SCHEMBL4761946 | 0.80 | TAS1R3 (0.50) | NPC1ALDH1A1 | |
| SCHEMBL7037396 | 0.80 | NPC1 (0.39) | NPC1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL4768735 | 0.80 | CTSK (0.36) | NPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4770129 | 0.74 | LMNA (0.37) | NPC1LMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL4770136 | 0.71 | HPGD (0.36) | NPC1IDO1LMNAMEN1KMT2A | |
| SCHEMBL6630600 | 0.71 | CTSK (0.48) | NPC1 | |
| SCHEMBL6630605 | 0.71 | CTSK (0.48) | NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307204-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-06-02 | — | — | EP | disclosed |
| EP-1307204-A1 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2003-05-07 | — | — | EP | disclosed |
| WO-2001095911-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-20 | — | — | WO | disclosed |