Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.58 |
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CASP1 | P29466 | 3/20 | 0.44 |
| ▸ | CASP7 | P55210 | 3/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11723689 | 0.82 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1664109 | 0.82 | ALDH1A1 (0.53) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL6986420 | 0.81 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL16720746 | 0.80 | USP14 (0.44) | ALDH1A1KDM4EMAPTBRPF1MAPK1 | |
| SCHEMBL30446730 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL1885602 | 0.80 | ALDH1A1 (0.55) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL11988035 | 0.79 | AVPR1A (0.45) | ALDH1A1MEN1KMT2AKDM4ECASP1 | |
| SCHEMBL3128695 | 0.79 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL4405521 | 0.76 | HSD17B10 (0.61) | ALDH1A1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL17505192 | 0.75 | BRPF1 (0.56) | ALDH1A1MEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1432415-A1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | Bayer HealthCare AG (DE) | 2004-06-30 | — | — | EP | disclosed |
| WO-2003028719-A1 | SUBSTITUTED 2,5-DIAMIDOINDOLES AS ECE INHIBITORS FOR THE TREATMENT OF CARDIOVASCULAR DISEASES | BAYER HEALTHCARE AG (DE) | 2003-04-10 | — | — | WO | disclosed |