Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | GLS | O94925 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6166534 | 0.88 | KAT6A (0.35) | KAT6ALMNAAPOBEC3ACASP7CASP6 | |
| SCHEMBL6608216 | 0.87 | L3MBTL1 (0.41) | KAT6ALMNAL3MBTL1ALDH1A1GLS | |
| SCHEMBL6612425 | 0.79 | NOTUM (0.37) | APOBEC3ACASP7CASP6APOBEC3GTDP1 | |
| SCHEMBL6624991 | 0.79 | KAT6A (0.39) | KAT6ALMNAAPOBEC3ACASP7CASP6 | |
| SCHEMBL6607778 | 0.78 | HSD11B1 (0.44) | APOBEC3ACASP7CASP6APOBEC3GTDP1 | |
| SCHEMBL6166386 | 0.78 | NOTUM (0.38) | APOBEC3ACASP7CASP6APOBEC3GTDP1 | |
| SCHEMBL6609458 | 0.77 | GSK3B (0.43) | LMNARAB9AALDH1A1MEN1KMT2A | |
| SCHEMBL6166140 | 0.76 | L3MBTL1 (0.38) | KAT6ALMNAL3MBTL1GLSRXFP1 | |
| SCHEMBL6689698 | 0.76 | L3MBTL1 (0.41) | L3MBTL1ALDH1A1MEN1KMT2AMAPK10 | |
| SCHEMBL6164798 | 0.75 | RAB9A (0.38) | APOBEC3ACASP7CASP6APOBEC3GTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |