Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.42 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.42 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.42 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.42 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.42 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.42 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.40 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6607136 | 0.85 | ALDH1A1 (0.43) | MAPTGRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL5722687 | 0.84 | GRIK1 (0.53) | MAPTGRIK1GRIA1GRIA2GRIA3 | |
| SCHEMBL6602007 | 0.83 | ALDH1A1 (0.47) | MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6607045 | 0.80 | ALDH1A1 (0.43) | MAPTMITFALDH1A1SMN1; SMN2 | |
| SCHEMBL6602596 | 0.78 | ALDH1A1 (0.41) | MAPTMITFALDH1A1SMN1; SMN2 | |
| SCHEMBL6602905 | 0.76 | GFER (0.52) | MAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6380913 | 0.76 | GRIA1 (0.41) | GRIA1GRIA2GRIA3GRIA4MITF | |
| SCHEMBL6604726 | 0.75 | ALDH1A1 (0.38) | MAPTMITFALDH1A1SMN1; SMN2 | |
| SCHEMBL6601059 | 0.74 | GRIA1 (0.42) | MAPTGRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL8369082 | 0.74 | PPARG (0.43) | MAPTMITFALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020453-B1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERIVATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN SEIYAKU KK (JP) | 2004-05-19 | — | — | EP | disclosed |
| US-6348461-B1 | CENTRAL NERVOUS SYSTEM ANTAGONIST WITH HETEROCYCLIC SUBSTITUENTS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2002-02-19 | — | — | US | disclosed |
| EP-1020453-A1 | 6,7-ASYMMETRICALLY DISUBSTITUTED QUINOXALINECARBOXYLIC ACID DERI VATIVES, ADDITION SALTS THEREOF, AND PROCESSES FOR THE PREPARATION OF BOTH | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |