Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165612 | 0.90 | ALDH1A1 (0.38) | TP53MAPTLMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL6608216 | 0.83 | L3MBTL1 (0.41) | LMNAALDH1A1L3MBTL1POLB | |
| SCHEMBL6689698 | 0.83 | L3MBTL1 (0.41) | ALDH1A1L3MBTL1POLB | |
| SCHEMBL6624416 | 0.79 | POLB (0.40) | MAPTALDH1A1SMN1; SMN2L3MBTL1POLB | |
| SCHEMBL27615910 | 0.78 | POLB (0.43) | POLB | |
| SCHEMBL6626827 | 0.78 | HSD11B1 (0.40) | ALDH1A1L3MBTL1POLB | |
| SCHEMBL27597137 | 0.77 | POLB (0.43) | ALDH1A1L3MBTL1POLB | |
| SCHEMBL27597143 | 0.76 | POLB (0.44) | ALDH1A1L3MBTL1POLBTSHR | |
| SCHEMBL27615839 | 0.76 | SCN5A (0.47) | ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL7699016 | 0.76 | ALDH1A1 (0.44) | TP53MAPTLMNAALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1379511-B1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | HOFFMANN LA ROCHE (CH) | 2005-07-20 | — | — | EP | disclosed |
| EP-1379511-A1 | DIHYDRO-BENZO (b) (1, 4) DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2004-01-14 | — | — | EP | disclosed |
| WO-2002083652-A1 | DIHYDRO-BENZO [b] [1, 4] DIAZEPIN-2-ONE DERIVATIVES AS MGLUR2 ANTAGONISTS II | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-24 | — | — | WO | disclosed |