Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | BCL9 | O00512 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5696642 | 0.86 | KMT2A (0.59) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL248163 | 0.80 | GAA (0.50) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL18087017 | 0.80 | LMNA (0.53) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL128042 | 0.80 | KMT2A (0.58) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL27283394 | 0.80 | LMNA (0.66) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL130836 | 0.77 | BCL9 (0.56) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL28905911 | 0.77 | LMNA (0.50) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL11230246 | 0.76 | KMT2A (0.39) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL1978709 | 0.76 | ALOX15 (0.45) | KMT2ALMNAALDH1A1MAPTHTT | |
| SCHEMBL7928066 | 0.76 | KMT2A (0.53) | KMT2ALMNAALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140895-B1 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-03-24 | — | — | EP | claimed |
| WO-2003018019-A2 | NEW USE OF CYCLIC COMPOUNDS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2003-03-06 | — | — | WO | claimed |
| EP-1140895-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | claimed |
| WO-2000040576-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-13 | — | — | WO | claimed |
| EP-0655461-B1 | Cyclic amino acid derivatives having ACE and NEP inhibiting activity | NOVARTIS AG (CH) | 2000-06-07 | — | — | EP | claimed |
| WO-1997011717-A1 | TREATMENT OF CHRONIC PROGRESSIVE RENAL FAILURE | NOVARTIS AG (CH) | 1997-04-03 | — | — | WO | claimed |
| US-5506244-A | TREATING CARDIOVASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | claimed |
| EP-0655461-A1 | Cyclic amino acid derivatives having ACE and NEP inhibiting activity | CIBA-GEIGY AG (CH) | 1995-05-31 | — | — | EP | claimed |
| EP-1140895-B1 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO (JP) | 2004-03-24 | — | — | EP | disclosed |
| EP-1140895-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040576-A2 | THIOPYRAN COMPOUNDS AS INHIBITORS OF MMP | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-13 | — | — | WO | disclosed |
| EP-0655461-B1 | Cyclic amino acid derivatives having ACE and NEP inhibiting activity | NOVARTIS AG (CH) | 2000-06-07 | — | — | EP | disclosed |
| US-5668158-A | TREATMENT OF CARDIOVASCULAR DISORDERS | NOVARTIS CORPORATION (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1997011717-A1 | TREATMENT OF CHRONIC PROGRESSIVE RENAL FAILURE | NOVARTIS AG (CH) | 1997-04-03 | — | — | WO | disclosed |
| US-5506244-A | TREATING CARDIOVASCULAR DISORDERS | CIBA-GEIGY CORPORATION (US) | 1996-04-09 | — | — | US | disclosed |
| US-5432186-A | Enzyme inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-07-11 | — | — | US | disclosed |
| EP-0655461-A1 | Cyclic amino acid derivatives having ACE and NEP inhibiting activity | CIBA-GEIGY AG (CH) | 1995-05-31 | — | — | EP | disclosed |