Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614137 | 0.94 | SIGMAR1 (0.48) | CCR5SIGMAR1 | |
| SCHEMBL6612912 | 0.94 | SIGMAR1 (0.45) | CCR5SIGMAR1 | |
| SCHEMBL6611718 | 0.93 | CCR5 (0.46) | CCR5SIGMAR1 | |
| SCHEMBL6612822 | 0.93 | CCR5 (0.46) | CCR5SIGMAR1 | |
| SCHEMBL6613639 | 0.91 | OPRL1 (0.46) | CCR5CHRM2SIGMAR1OPRM1OPRD1 | |
| SCHEMBL6612342 | 0.85 | CCR5 (0.43) | CCR5LMNACHRM2ADRA2ACYP2D6 | |
| SCHEMBL6612781 | 0.84 | LMNA (0.53) | LMNACHRM2ADRA2ACYP2D6TSHR | |
| SCHEMBL6613785 | 0.83 | CCR5 (0.34) | CCR5 | |
| SCHEMBL6610931 | 0.82 | CXCR3 (0.55) | CCR5 | |
| SCHEMBL6611036 | 0.82 | CCR5 (0.52) | CCR5LMNACHRM2ADRA2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1236726-B1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1236726-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-09-04 | — | — | EP | disclosed |