Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 5/20 | 0.55 |
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.55 |
| ▸ | DRD3 | P35462 | 2/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.55 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | HTR2B | P41595 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614882 | 0.89 | HTR2A (0.51) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL6612040 | 0.86 | DRD3 (0.56) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL6610961 | 0.85 | HTR1A (0.59) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL6617707 | 0.84 | HTR1A (0.63) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL6612983 | 0.83 | HTR1A (0.62) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL6611417 | 0.83 | HTR1A (0.62) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL6612492 | 0.82 | HTR1A (0.46) | DRD2HTR1AKMT2AMAPTLMNA | |
| SCHEMBL6617457 | 0.81 | DRD2 (0.50) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL6609843 | 0.79 | CXCR3 (0.49) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL6012396 | 0.78 | DRD2 (0.44) | DRD2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1236726-B1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1236726-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-09-04 | — | — | EP | disclosed |