Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.42 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6612492 | 0.86 | HTR1A (0.46) | DRD2SIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6012562 | 0.84 | OPRL1 (0.52) | DRD2SIGMAR1OPRM1OPRD1OPRK1 | |
| SCHEMBL6012726 | 0.83 | CXCR3 (0.59) | OPRM1OPRD1OPRK1OPRL1CXCR3 | |
| SCHEMBL6611549 | 0.82 | OPRM1 (0.45) | DRD2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL6611036 | 0.82 | CCR5 (0.52) | SIGMAR1OPRM1CXCR3CCR5 | |
| SCHEMBL6012235 | 0.81 | BDKRB2 (0.40) | OPRM1OPRD1OPRK1OPRL1CXCR3 | |
| SCHEMBL6034619 | 0.81 | TMEM97 (0.35) | DRD2SIGMAR1SLC6A9ALDH1A1 | |
| SCHEMBL6612342 | 0.81 | CCR5 (0.43) | DRD2SIGMAR1OPRM1SLC6A9ALDH1A1 | |
| SCHEMBL6614177 | 0.80 | CCR5 (0.57) | SIGMAR1CXCR3CCR5 | |
| SCHEMBL6615208 | 0.79 | CCR5 (0.61) | SIGMAR1OPRM1CXCR3CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7119091-B2 | Triazaspiro[5.5]undecane derivatives and pharmaceutical compositions comprising thereof, as an active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-10-10 | — | — | US | disclosed |
| EP-1236726-B1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO (JP) | 2004-12-01 | — | — | EP | disclosed |
| EP-1236726-A1 | TRIAZASPIRO 5.5]UNDECANE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-09-04 | — | — | EP | disclosed |