Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 4/20 | 0.41 |
| ▸ | NAMPT | P43490 | 3/20 | 0.41 |
| ▸ | GIPR | P48546 | 3/20 | 0.41 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6615051 | 0.91 | SCN2A (0.42) | TRPV1MAPTGCGRNAMPTGIPR | |
| SCHEMBL6619833 | 0.89 | TRPV1 (0.43) | TRPV1GCGRNAMPTGIPRABL1 | |
| SCHEMBL6615889 | 0.88 | TRPV1 (0.45) | TRPV1EPHX2GCGRNAMPTGIPR | |
| SCHEMBL6605931 | 0.88 | ACKR3 (0.43) | TRPV1MAPTEPHX2NR1H4ACKR3 | |
| SCHEMBL6616422 | 0.86 | NAMPT (0.45) | TRPV1EPHX2NR1H4GCGRNAMPT | |
| SCHEMBL6617192 | 0.85 | MAPT (0.43) | MAPTEPHX2NR1H4ACKR3NAMPT | |
| SCHEMBL6615997 | 0.85 | GCGR (0.45) | TRPV1EPHX2NR1H4GCGRNAMPT | |
| SCHEMBL6619980 | 0.85 | GCGR (0.45) | EPHX2NR1H4ACKR3GCGRNAMPT | |
| SCHEMBL6616371 | 0.85 | ACKR3 (0.43) | MAPTACKR3LMNASMN1; SMN2 | |
| SCHEMBL6615756 | 0.85 | NAMPT (0.42) | EPHX2NR1H4GCGRNAMPTGIPR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |