Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | KDM2B | Q8NHM5 | 3/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 4/20 | 0.41 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4050942 | 0.85 | GRIN1 (0.51) | HRH3HTR2A | |
| SCHEMBL6617305 | 0.80 | CHRNB4 (0.47) | HRH3CHRNB4CHRNA3 | |
| SCHEMBL6619348 | 0.79 | CHRNB4 (0.47) | KDM2BABCB1CCR3HTR2ACYP2D6 | |
| SCHEMBL6617259 | 0.78 | CHRNB4 (0.42) | CCR3CYP2D6CHRNB4CHRNA3 | |
| SCHEMBL6618307 | 0.78 | CACNA1B (0.44) | MAOBCCR3CHRNB4CHRNA3 | |
| SCHEMBL6647024 | 0.77 | SSTR5 (0.47) | HTR2ACHRNB4CHRNA3 | |
| SCHEMBL6659265 | 0.77 | POLB (0.44) | CYP2D6CHRNB4CHRNA3 | |
| SCHEMBL6614327 | 0.76 | CYP3A4 (0.48) | MAOBCCR3CYP2D6 | |
| SCHEMBL6648474 | 0.75 | PTGS1 (0.46) | CCR3CYP2D6 | |
| SCHEMBL6618399 | 0.75 | MEN1 (0.48) | MAOAMAOBCCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1421070-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | AstraZeneca AB (SE) | 2004-05-26 | — | — | EP | disclosed |
| WO-2003018566-A1 | NEW PIPERIDINYL DERIVATES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2003-03-06 | — | — | WO | disclosed |