Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30460419 | 1.00 | ALOX15 (0.58) | ALOX15SMN1; SMN2MAPTTSHRKDM4E | |
| SCHEMBL3139167 | 0.86 | HTR1A (0.48) | ALOX15SMN1; SMN2MAPTKDM4EHTT | |
| SCHEMBL30460410 | 0.86 | HTR1A (0.48) | ALOX15SMN1; SMN2MAPTKDM4EHTT | |
| SCHEMBL7432703 | 0.84 | KDM4E (0.47) | ALOX15SMN1; SMN2MAPTKDM4EHTT | |
| SCHEMBL24938760 | 0.82 | ALOX15 (0.59) | ALOX15SMN1; SMN2MAPTTSHRKDM4E | |
| SCHEMBL7431417 | 0.82 | KDM4E (0.45) | ALOX15SMN1; SMN2MAPTKDM4EHTT | |
| SCHEMBL6610000 | 0.82 | TSHR (0.49) | ALOX15MAPTTSHRKDM4EHTT | |
| SCHEMBL7533220 | 0.81 | ALOX15 (0.58) | ALOX15SMN1; SMN2MAPTTSHRKDM4E | |
| SCHEMBL3610243 | 0.81 | MAPT (0.77) | ALOX15SMN1; SMN2MAPTTSHRKDM4E | |
| SCHEMBL3046007 | 0.81 | ALOX15 (0.58) | ALOX15SMN1; SMN2MAPTTSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4740944-A2 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H-[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | Actuate Therapeutics Inc. (US) | 2026-05-13 | — | — | EP | disclosed |
| US-20250115615-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS, INC. | 2025-04-10 | — | — | US | disclosed |
| US-20250115616-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS INC. | 2025-04-10 | — | — | US | disclosed |
| US-12145943-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS INC. (US) | 2024-11-19 | — | — | US | disclosed |
| US-12116374-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | ACTUATE THERAPEUTICS INC. (US) | 2024-10-15 | — | — | US | disclosed |
| CN-111247153-B | Solid forms of 3- (5-fluorobenzofuran-3-yl) -4- (5-methyl-5H- [1,3] dioxolo [4,5-f ] indol-7-yl) pyrrole-2,5-dione | 开动疗法公司 | 2024-04-02 | — | — | CN | disclosed |
| EP-3665176-B1 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | ACTUATE THERAPEUTICS INC (US) | 2024-01-24 | — | — | EP | disclosed |
| EP-3665176-B1 | SOLID FORMS OF 3-(5-FLUOROBENZOFURAN-3-YL)-4-(5-METHYL-5H[1,3]DIOXOLO[4,5-F]INDOL-7-YL)PYRROLE-2,5-DIONE | ACTUATE THERAPEUTICS INC (US) | 2024-01-24 | — | — | EP | disclosed |
| CN-117362305-A | Solid forms of 9-ING-41 | 开动疗法公司 | 2024-01-09 | — | — | CN | disclosed |
| CN-111315748-B | 3- (5-fluorobenzofuran-3-yl) -4- (5-methyl-5H- [1,3] dioxolo [4,5-f ] indol-7-yl) pyrrole-2, 5-dione crystals | 开动疗法公司 | 2023-06-27 | — | — | CN | disclosed |
| EP-1149087-B1 | PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES, THEIR PREPARATION AND USE | LUNDBECK & CO AS H (DK) | 2004-04-07 | — | — | EP | disclosed |
| US-6596722-B2 | Serotonin reuptake inhibitors/HT3 receptor antagonists useful for treatment of depression, psychosis, anxiety disorders, panic disorder, obsessive compulsive disorder, and eating disorders | H. LUNDBECK A/S (DK) | 2003-07-22 | — | — | US | disclosed |
| US-20020173512-A1 | Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use | H. LUNDBECK A/S | 2002-11-21 | — | — | US | disclosed |
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-09-12 | — | — | US | disclosed |
| US-6391882-B1 | PSYCHOLOGICAL DISORDERS; ANTIDEPRESSANTS | H. LUNDBECK A/S (DK) | 2002-05-21 | — | — | US | disclosed |
| US-20020035113-A1 | Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2002-03-21 | — | — | US | disclosed |
| EP-1149087-A1 | PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES, THEIR PREPARATION AND USE | H. Lundbeck A/S (DK) | 2001-10-31 | — | — | EP | disclosed |
| EP-1089997-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H.Lundbeck A/S (DK) | 2001-04-11 | — | — | EP | disclosed |
| WO-2000043382-A1 | PIPERIDINE, TETRAHYDROPYRIDINE AND PIPERAZINE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2000-07-27 | — | — | WO | disclosed |
| WO-1999067237-A1 | 4,5,6 AND 7-INDOLE AND INDOLINE DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12145943-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | DHPS, PDCD5, IPO5 | ALOX15 1141/4885SMN1; SMN2 782/4885MAPT 784/4885 |
| US-20250115616-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | DHPS, PDCD5, IPO5 | ALOX15 1141/4885SMN1; SMN2 782/4885MAPT 784/4885 |
| US-20020128272-A1 | 4,5,6, and 7-indole and indoline derivatives, their preparation and use | HTR2C, HTR1A, HTR7 | ALOX15 2590/4885SMN1; SMN2 3596/4885MAPT 2061/4885 |
| US-20020035113-A1 | Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use | DRD1, DRD2, H1-5 | ALOX15 2296/4885SMN1; SMN2 2746/4885MAPT 4197/4885 |
| US-12116374-B2 | Solid forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | DHPS, PDCD5, IPO5 | ALOX15 1141/4885SMN1; SMN2 782/4885MAPT 784/4885 |
| US-20250115615-A1 | Solid Forms of 3-(5-Fluorobenzofuran-3-yl)-4-(5-methyl-5H-[1,3]dioxolo[4,5-f]indol-7-yl)pyrrole-2,5-dione | VHL, DHPS, PDCD5 | ALOX15 1351/4885SMN1; SMN2 553/4885MAPT 707/4885 |
| US-20020173512-A1 | Piperidine, tetrahydropyridine and piperazine derivatives, their preparation and use | DRD1, DRD2, H1-5 | ALOX15 2296/4885SMN1; SMN2 2746/4885MAPT 4197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.