Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
| ▸ | REN | P00797 | 1/20 | 0.37 |
| ▸ | TACR3 | P29371 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11942312 | 0.82 | KDM4E (0.47) | KDM4ETP53NCF1ALDH1A1GAA | |
| SCHEMBL660585 | 0.80 | KDM4E (0.44) | KDM4ETP53NCF1ALDH1A1REN | |
| SCHEMBL1228082 | 0.76 | KDM4E (0.58) | KDM4ETP53ALDH1A1GAAMCL1 | |
| SCHEMBL1228546 | 0.74 | REN (0.39) | KDM4ETP53NCF1ALDH1A1GAA | |
| SCHEMBL27774889 | 0.74 | NCF1 (0.43) | KDM4ENCF1PDE10A | |
| SCHEMBL662410 | 0.73 | KDM4E (0.56) | KDM4ETP53ALDH1A1GAAPDE10A | |
| SCHEMBL19651360 | 0.72 | NPC1 (0.44) | KDM4EALDH1A1GAAPDE10AMEN1 | |
| SCHEMBL23152002 | 0.72 | LMNA (0.48) | KDM4EALDH1A1GAAMCL1MEN1 | |
| SCHEMBL29935837 | 0.72 | LMNA (0.48) | KDM4EALDH1A1GAAMCL1MEN1 | |
| SCHEMBL664247 | 0.71 | REN (0.42) | TP53NCF1ALDH1A1RENTACR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2012-02-23 | — | — | US | disclosed |
| US-8063105-B2 | Renin inhibitors | MERCK CANADA INC. (CA) | 2011-11-22 | — | — | US | disclosed |
| US-20090281103-A1 | Renin Inhibitors | MERCK CANADA INC. (CA) | 2009-11-12 | — | — | US | disclosed |
| EP-1910272-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007009250-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2007-01-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046293-A1 | RENIN INHIBITORS | REN, ACE, AGTR1 | KDM4E 3884/4885TP53 4790/4885NCF1 3034/4885 |
| US-20090281103-A1 | Renin Inhibitors | REN, ACE, AGT | KDM4E 3615/4885TP53 4862/4885NCF1 2366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.