Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 8/20 | 0.58 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GPR6 | P46095 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.37 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6613905 | 0.92 | P2RX7 (0.49) | P2RX7KCNJ11L3MBTL1MAPTKDM4E | |
| SCHEMBL6615879 | 0.91 | P2RX7 (0.48) | P2RX7KCNJ11L3MBTL1MAPTNPC1 | |
| SCHEMBL6644164 | 0.88 | RAB9A (0.55) | P2RX7KCNJ11L3MBTL1MAPTKDM4E | |
| SCHEMBL4682449 | 0.81 | KCNJ11 (0.69) | P2RX7KCNJ11L3MBTL1MAPTKDM4E | |
| SCHEMBL4682445 | 0.81 | KCNJ11 (0.69) | P2RX7KCNJ11L3MBTL1MAPTKDM4E | |
| SCHEMBL6611088 | 0.80 | KCNJ11 (0.46) | P2RX7KCNJ11L3MBTL1MAPTKDM4E | |
| SCHEMBL6640615 | 0.79 | KCNJ11 (0.45) | P2RX7KCNJ11L3MBTL1MAPTKDM4E | |
| SCHEMBL7742276 | 0.79 | ABCC9 (0.56) | KCNJ11MAPTKDM4EMEN1KMT2A | |
| SCHEMBL6613703 | 0.76 | KCNQ3 (0.54) | KCNJ11 | |
| SCHEMBL7140862 | 0.74 | KCNJ11 (0.55) | P2RX7KCNJ11L3MBTL1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1392655-A2 | POTASSIUM CHANNEL OPENERS | Abbott Laboratories (US) | 2004-03-03 | — | — | EP | claimed |
| WO-2002062762-A2 | POTASSIUM CHANNEL OPENERS | ABBOTT LABORATORIES (US) | 2002-08-15 | — | — | WO | claimed |