Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6616751 | 0.93 | CRACR2A (0.45) | NPC1CRACR2APKMMAPTMEN1 | |
| SCHEMBL6617585 | 0.91 | ALDH1A1 (0.43) | NPC1RAB9ALMNAKDM4EGLA | |
| SCHEMBL6616443 | 0.88 | CRACR2A (0.42) | CRACR2AMAPT | |
| SCHEMBL6615270 | 0.88 | CRACR2A (0.44) | NPC1RAB9ACRACR2AKDM4EMAPT | |
| SCHEMBL6618517 | 0.88 | KDM4E (0.45) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL6618198 | 0.88 | RAB9A (0.41) | NPC1RAB9ALMNAKDM4EPKM | |
| SCHEMBL6619166 | 0.87 | MAPT (0.44) | NPC1RAB9ALMNAKDM4EGLA | |
| SCHEMBL6615822 | 0.86 | KCNMA1 (0.41) | CRACR2AKDM4EGLAMAPTMEN1 | |
| SCHEMBL6615130 | 0.85 | ABCG2 (0.42) | NPC1RAB9AGLAMAPTMEN1 | |
| SCHEMBL6619198 | 0.85 | CRACR2A (0.44) | CRACR2AMAPTMEN1KMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |