Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617233 | 0.93 | NPC1 (0.43) | CRACR2ANPC1HPGDKMT2AMAPT | |
| SCHEMBL6615270 | 0.92 | CRACR2A (0.44) | CRACR2ANPC1ALDH1A1HPGDKMT2A | |
| SCHEMBL6616443 | 0.91 | CRACR2A (0.42) | CRACR2AALDH1A1MAPTAVPR2PTGES | |
| SCHEMBL6618455 | 0.91 | LMNA (0.39) | CRACR2AALDH1A1POLBHPGDKMT2A | |
| SCHEMBL6619787 | 0.90 | MAPK14 (0.41) | NPC1ALDH1A1POLBKMT2AMAPT | |
| SCHEMBL6608341 | 0.89 | POLB (0.44) | NPC1ALDH1A1POLBHPGDKMT2A | |
| SCHEMBL6615822 | 0.88 | KCNMA1 (0.41) | CRACR2APOLBHPGDKMT2AMAPT | |
| SCHEMBL6619198 | 0.88 | CRACR2A (0.44) | CRACR2AKMT2AMAPTSMN1; SMN2MEN1 | |
| SCHEMBL6603282 | 0.88 | CRACR2A (0.45) | CRACR2ANPC1ALDH1A1POLBHPGD | |
| SCHEMBL6661397 | 0.88 | CRACR2A (0.45) | CRACR2AALDH1A1POLBHPGDKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |