Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | GNRHR | P30968 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618519 | 0.91 | ALDH1A1 (0.42) | NPSR1NPC1RAB9AKMT2AMAPT | |
| SCHEMBL6618768 | 0.91 | MEN1 (0.46) | NPSR1SMN1; SMN2NPC1RAB9AKMT2A | |
| SCHEMBL6621361 | 0.90 | JAK2 (0.43) | ELANESMN1; SMN2F2KMT2AMEN1 | |
| SCHEMBL6673259 | 0.89 | NAMPT (0.41) | RAB9AKMT2AMAPTALDH1A1MEN1 | |
| SCHEMBL6617610 | 0.88 | KMT2A (0.40) | KMT2AMAPTTSHRMEN1 | |
| SCHEMBL6617082 | 0.88 | TERT (0.36) | SMN1; SMN2NPC1RAB9AKMT2AALDH1A1 | |
| SCHEMBL6616388 | 0.88 | NAMPT (0.37) | NPSR1GNRHRMAPTHSD17B10 | |
| SCHEMBL6615563 | 0.86 | TERT (0.36) | SMN1; SMN2NPC1RAB9AKMT2AMAPT | |
| SCHEMBL6617884 | 0.86 | ACKR3 (0.42) | SMN1; SMN2NPC1RAB9AKMT2AMAPT | |
| SCHEMBL6618278 | 0.86 | MEN1 (0.45) | SMN1; SMN2RAB9AKMT2AMAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |