Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 4/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.40 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6603139 | 0.91 | BRAF (0.40) | MEN1KMT2APOLBCNR1NAMPT | |
| SCHEMBL6618170 | 0.91 | MEN1 (0.47) | MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL6618768 | 0.91 | MEN1 (0.46) | MEN1KMT2APOLBSMN1; SMN2 | |
| SCHEMBL6617523 | 0.90 | NPSR1 (0.44) | MEN1KMT2AF2ELANESMN1; SMN2 | |
| SCHEMBL6617364 | 0.89 | CNR1 (0.42) | JAK2POLBCNR1SMN1; SMN2NAMPT | |
| SCHEMBL6617462 | 0.87 | CNR1 (0.39) | MEN1KMT2APOLBCNR1SMN1; SMN2 | |
| SCHEMBL6618534 | 0.87 | NPY2R (0.38) | MEN1KMT2APOLBCNR1NAMPT | |
| SCHEMBL6634119 | 0.87 | CNR1 (0.42) | JAK2POLBCNR1SMN1; SMN2NAMPT | |
| SCHEMBL6615537 | 0.86 | LMNA (0.45) | JAK2KMT2APOLBNAMPT | |
| SCHEMBL6618100 | 0.86 | CNR1 (0.41) | MEN1KMT2ACNR1SMN1; SMN2NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |