Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 4/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 4/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TYK2 | P29597 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6618339 | 0.92 | ACKR3 (0.44) | ACKR3MAPTRAB9ANPC1GLA | |
| SCHEMBL6616478 | 0.92 | ACKR3 (0.44) | ACKR3MAPTRAB9ANPC1GLA | |
| SCHEMBL6622049 | 0.90 | RAB9A (0.39) | RAB9AMEN1KMT2ATYK2 | |
| SCHEMBL6620593 | 0.89 | HRH3 (0.39) | ACKR3MAPTRAB9ACNR1TYK2 | |
| SCHEMBL6617585 | 0.89 | ALDH1A1 (0.43) | ACKR3MAPTRAB9ANPC1GLA | |
| SCHEMBL6617030 | 0.86 | MEN1 (0.49) | MAPTRAB9ANPC1GLAMEN1 | |
| SCHEMBL6617954 | 0.86 | EPHX2 (0.40) | CNR1TYK2 | |
| SCHEMBL6617644 | 0.86 | ACKR3 (0.40) | ACKR3MAPTCNR1ALDH1A1TYK2 | |
| SCHEMBL6615885 | 0.85 | NPC1 (0.47) | ACKR3MAPTRAB9ANPC1MEN1 | |
| SCHEMBL6619639 | 0.85 | DRD2 (0.43) | MAPTRAB9ANPC1GLAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |