Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.42 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | SENP5 | Q96HI0 | 2/20 | 0.39 |
| ▸ | SENP2 | Q9HC62 | 2/20 | 0.39 |
| ▸ | SENP1 | Q9P0U3 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6619698 | 0.92 | SENP1 (0.46) | IMPDH2HDAC1BTKSENP5SENP2 | |
| SCHEMBL6621958 | 0.91 | HDAC2 (0.44) | IMPDH2HDAC1BTKSENP5SENP2 | |
| SCHEMBL6616793 | 0.88 | SENP1 (0.41) | IMPDH2BTKSENP5SENP2SENP1 | |
| SCHEMBL6614975 | 0.86 | SENP1 (0.45) | HDAC1BTKSENP5SENP2SENP1 | |
| SCHEMBL6602256 | 0.86 | RAB9A (0.41) | IMPDH2HDAC1SENP5SENP2SENP1 | |
| SCHEMBL6616301 | 0.85 | ALDH1A1 (0.48) | MAPTTP53GAAKMT2A | |
| SCHEMBL6613706 | 0.85 | HDAC2 (0.43) | HDAC1BTKSENP5SENP2SENP1 | |
| SCHEMBL6616434 | 0.85 | TMIGD3 (0.39) | IMPDH2BTKSENP5SENP2SENP1 | |
| SCHEMBL6616205 | 0.85 | HTR3A (0.44) | CLK1IMPDH2HDAC1SENP5SENP2 | |
| SCHEMBL6618339 | 0.85 | ACKR3 (0.44) | MAPTTP53GLACYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |