Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617385 | 0.94 | LMNA (0.39) | LMNADHODHALDH1A1HPGDMAPT | |
| SCHEMBL6621042 | 0.94 | ACKR3 (0.40) | LMNAALDH1A1HPGDACKR3KDM4E | |
| SCHEMBL6619848 | 0.92 | PPARG (0.42) | ALDH1A1MAPTACKR3MEN1KMT2A | |
| SCHEMBL6617585 | 0.92 | ALDH1A1 (0.43) | LMNAALDH1A1HPGDMAPTACKR3 | |
| SCHEMBL6618795 | 0.92 | HRH3 (0.40) | LMNAMAPTACKR3 | |
| SCHEMBL6616751 | 0.91 | CRACR2A (0.45) | ALDH1A1HPGDMAPTACKR3CRACR2A | |
| SCHEMBL6620229 | 0.89 | PPARG (0.42) | MAPTGRM4CRACR2AMEN1KMT2A | |
| SCHEMBL6617068 | 0.89 | PKM (0.38) | LMNAALDH1A1HPGDMAPTACKR3 | |
| SCHEMBL6618849 | 0.88 | CHRM5 (0.40) | MAPTACKR3GRM4CRACR2ACHRM5 | |
| SCHEMBL6603314 | 0.87 | PPARG (0.40) | LMNAALDH1A1HPGDMAPTACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |