Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.42 |
| ▸ | CTSB | P07858 | 3/20 | 0.42 |
| ▸ | CTSL | P07711 | 3/20 | 0.42 |
| ▸ | CTSK | P43235 | 3/20 | 0.42 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | BACE1 | P56817 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | WNT3A | P56704 | 1/20 | 0.38 |
| ▸ | GLS | O94925 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6927161 | 1.00 | CTSS (0.42) | CTSSCTSBCTSLCTSKKLK5 | |
| SCHEMBL6619904 | 0.92 | REN (0.46) | CTSSCTSBCTSLCTSKBACE1 | |
| SCHEMBL7608375 | 0.87 | CTSL (0.44) | CTSSCTSBCTSLCTSKF2 | |
| SCHEMBL6929841 | 0.85 | REN (0.45) | CTSSCTSBCTSLCTSKBACE1 | |
| SCHEMBL7830240 | 0.82 | CTSL (0.39) | CTSSCTSBCTSLCTSKKLK5 | |
| SCHEMBL7616026 | 0.81 | CTSL (0.46) | CTSSCTSBCTSLCTSKWNT3A | |
| SCHEMBL6670621 | 0.81 | CTSL (0.46) | CTSSCTSBCTSLCTSKWNT3A | |
| SCHEMBL6670617 | 0.81 | CTSL (0.46) | CTSSCTSBCTSLCTSKWNT3A | |
| SCHEMBL7611319 | 0.81 | CTSL (0.45) | CTSSCTSBCTSLCTSKF2 | |
| SCHEMBL7819471 | 0.78 | REN (0.47) | CTSSCTSBCTSLCTSKBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067894-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |
| EP-1067894-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999059526-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |