Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 10/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | PSEN1 | P49768 | 4/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 4/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 4/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 4/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 4/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 4/20 | 0.42 |
| ▸ | CTSK | P43235 | 2/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620241 | 0.92 | CTSS (0.42) | BACE1CTSKCTSBCTSSCTSL | |
| SCHEMBL6927161 | 0.92 | CTSS (0.42) | BACE1CTSKCTSBCTSSCTSL | |
| SCHEMBL6929841 | 0.90 | REN (0.45) | RENBACE1CTSKCTSBCTSS | |
| SCHEMBL7819471 | 0.86 | REN (0.47) | RENBACE1PSEN1PSEN2APH1B | |
| SCHEMBL7611319 | 0.84 | CTSL (0.45) | CTSKCTSBCTSSCTSLCTSD | |
| SCHEMBL7608375 | 0.80 | CTSL (0.44) | CTSKCTSBCTSSCTSL | |
| SCHEMBL7617864 | 0.79 | CTSL (0.43) | CTSKCTSBCTSSCTSLCTSD | |
| SCHEMBL7473368 | 0.79 | CTSK (0.52) | CTSKCTSBCTSSCTSL | |
| SCHEMBL7830240 | 0.78 | CTSL (0.39) | BACE1CTSKCTSBCTSSCTSL | |
| SCHEMBL7616026 | 0.76 | CTSL (0.46) | CTSKCTSBCTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067894-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2004-09-08 | — | — | EP | disclosed |
| US-6518267-B1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2003-02-11 | — | — | US | disclosed |
| EP-1067894-A2 | PROTEASE INHIBITORS | SmithKline Beecham Corporation (US) | 2001-01-17 | — | — | EP | disclosed |
| WO-1999059526-A2 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-11-25 | — | — | WO | disclosed |