Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.41 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617837 | 1.00 | HTT (0.56) | HTTHPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL8110951 | 0.89 | HPGD (0.45) | HTTHPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6615711 | 0.77 | L3MBTL1 (0.39) | RAB9ANPC1SMN1; SMN2DYRK1AFGFR1 | |
| SCHEMBL6616860 | 0.77 | L3MBTL1 (0.39) | RAB9ANPC1SMN1; SMN2DYRK1AFGFR1 | |
| SCHEMBL6616738 | 0.75 | SMN1; SMN2 (0.58) | HPGDRAB9ANPC1SMN1; SMN2DYRK1A | |
| SCHEMBL30129312 | 0.73 | HPGD (1.00) | HTTHPGDRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL6618464 | 0.72 | ROCK2 (0.49) | DYRK1AFGFR1DYRK3CLK1CLK2 | |
| SCHEMBL6619697 | 0.72 | HTT (0.56) | HTTHPGDRAB9ANPC1DYRK1A | |
| SCHEMBL8112159 | 0.72 | HTT (0.56) | HTTHPGDRAB9ANPC1DYRK1A | |
| SCHEMBL6617454 | 0.72 | PDGFRB (0.61) | RAB9ANPC1DYRK1AFGFR1DYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-B1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | AVENTIS PHARMA INC (US) | 2004-06-23 | — | — | EP | disclosed |
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007658-A1 | PYRAZOLO[3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-03-14 | — | — | WO | disclosed |
| US-5476851-A | Administering as therapeutic agents for various disease states which are characterized by uncontrolled cellular proliferation | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1995-12-19 | — | — | US | disclosed |