Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.34 |
| ▸ | METAP1 | P53582 | 2/20 | 0.34 |
| ▸ | CBFB | Q13951 | 2/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617837 | 0.89 | HTT (0.56) | HPGDHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6621982 | 0.89 | HTT (0.56) | HPGDHTTSMN1; SMN2NPC1RAB9A | |
| SCHEMBL6616315 | 0.87 | CYP1A2 (0.46) | HPGDHTTCYP1A2GRIA1SMN1; SMN2 | |
| SCHEMBL6617020 | 0.87 | CYP1A2 (0.46) | HPGDHTTCYP1A2GRIA1SMN1; SMN2 | |
| SCHEMBL6616738 | 0.74 | SMN1; SMN2 (0.58) | HPGDCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6615711 | 0.71 | L3MBTL1 (0.39) | CYP1A2CYP2D6CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL6616860 | 0.71 | L3MBTL1 (0.39) | CYP1A2CYP2D6CYP2C9SMN1; SMN2NPC1 | |
| SCHEMBL6620239 | 0.68 | PIM1 (0.64) | HPGDCYP1A2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6621847 | 0.68 | TRPA1 (0.55) | SMN1; SMN2NPC1RAB9AKDM4EMAPT | |
| SCHEMBL8110919 | 0.68 | TRPA1 (0.55) | SMN1; SMN2NPC1RAB9AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779889-A4 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE POULENC RORER PHARMA (US) | 2000-02-23 | — | — | EP | disclosed |
| EP-0779889-A1 | PYRAZOLO 3,4-g]QUINOXALINE COMPOUNDS WHICH INHIBIT PDGF RECEPTOR PROTEIN TYROSINE KINASE | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1997-06-25 | — | — | EP | disclosed |