Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CCR5 | P51681 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
| ▸ | HTR6 | P50406 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6617262 | 0.87 | SIGMAR1 (0.48) | SIGMAR1CYP2D6CHRM3 | |
| SCHEMBL7978255 | 0.79 | CARM1 (0.51) | SIGMAR1CYP2D6CHRM3 | |
| SCHEMBL1808554 | 0.71 | DRD2 (0.54) | SIGMAR1CYP2D6DRD2CHRM3 | |
| SCHEMBL7235979 | 0.69 | SIGMAR1 (0.51) | SIGMAR1CYP2D6 | |
| SCHEMBL6198442 | 0.67 | SIGMAR1 (0.69) | SIGMAR1CYP2D6DRD2HTR7 | |
| SCHEMBL6620398 | 0.66 | CHRM2 (0.61) | CYP2D6DRD2HTR1AHTR6CHRM3 | |
| SCHEMBL6620370 | 0.66 | SIGMAR1 (0.53) | SIGMAR1CYP2D6 | |
| SCHEMBL7978211 | 0.65 | KDM1A (0.59) | DRD2HTR1ADRD3 | |
| SCHEMBL11482798 | 0.65 | SIGMAR1 (0.51) | SIGMAR1 | |
| SCHEMBL7867289 | 0.64 | BACE1 (0.46) | SIGMAR1CYP2D6CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979231-B1 | CONDENSED PYRIDAZINE DERIVATIVES, THEIR PRODUCTION AND USE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2004-11-24 | — | — | EP | disclosed |
| US-6627630-B1 | Preventing or treating allergic skin diseases such as contact dermatitis, pruritus, dried dermatitis, acute urticaria prurigo and antiallergins | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2003-09-30 | — | — | US | disclosed |
| EP-1243271-A1 | NASAL DROPS CONTAINING FUSED PYRIDAZINE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2002-09-25 | — | — | EP | disclosed |
| US-6248740-B1 | FOR SUPPRESSION OF HISTAMINE OR EOSINOPHIL CHEMOTAXIS TO TREAT ASTHMA; ANTIALLERGENIC | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-06-19 | — | — | US | disclosed |