Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.37 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.37 |
| ▸ | SMAD2 | Q15796 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6620807 | 0.86 | ALDH1A1 (0.48) | POLBMAPTALDH1A1KDM4EMEN1 | |
| SCHEMBL6623201 | 0.80 | MEN1 (0.46) | POLBMAPTALDH1A1KDM4ETDP1 | |
| SCHEMBL411466 | 0.76 | TGFBR1 (0.43) | MAPTALDH1A1ADORA2AADORA1NPC1 | |
| SCHEMBL6313738 | 0.73 | MAPT (0.49) | MAPTALDH1A1ADORA2AADORA1NPC1 | |
| SCHEMBL17141347 | 0.73 | ALDH1A1 (0.50) | MAPTALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6314174 | 0.71 | ALDH1A1 (0.47) | MAPTALDH1A1ADORA2AADORA1NPC1 | |
| SCHEMBL13629590 | 0.71 | KDM4E (0.56) | POLBMAPTALDH1A1KDM4ETDP1 | |
| SCHEMBL22816288 | 0.70 | ALDH1A1 (0.50) | POLBMAPTALDH1A1KDM4ETDP1 | |
| SCHEMBL22816289 | 0.70 | ALDH1A1 (0.50) | POLBMAPTALDH1A1KDM4ETDP1 | |
| SCHEMBL6796072 | 0.70 | AOC3 (0.38) | MAPTALDH1A1KDM4ETDP1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040266842-A1 | Thiazolyl substituted triazoles as alk5 inhibitors | GASTER LARAMIE MARY | 2004-12-30 | — | — | US | claimed |
| EP-1444227-A1 | THIAZOLYL SUBSTITUTED TRIAZOLES AS ALK5 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-08-11 | — | — | EP | claimed |
| WO-2003042207-A1 | THIAZOLYL SUBSTITUTED TRIAZOLES AS ALK5 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-22 | — | — | WO | claimed |
| US-20040266842-A1 | Thiazolyl substituted triazoles as alk5 inhibitors | GASTER LARAMIE MARY | 2004-12-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266842-A1 | Thiazolyl substituted triazoles as alk5 inhibitors | CBR3, CBR1, ALK | POLB 2560/4885MAPT 4735/4885ALDH1A1 1905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.