Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2096148 | 0.81 | MAPT (0.61) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL6622341 | 0.80 | POLB (0.40) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL17584763 | 0.79 | MEN1 (0.59) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL3663194 | 0.75 | MEN1 (0.43) | MEN1KMT2AGABRA1GABRG2GABRB3 | |
| SCHEMBL28444043 | 0.73 | ALOX15 (0.65) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL28070637 | 0.73 | MEN1 (0.49) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL408607 | 0.72 | TGFBR1 (0.56) | MEN1KMT2AMAPTALDH1A1HPGD | |
| SCHEMBL6796072 | 0.72 | AOC3 (0.38) | MAPTALDH1A1KDM4ETDP1LMNA | |
| SCHEMBL17141308 | 0.72 | MEN1 (0.51) | MEN1KMT2AMAPTALDH1A1KDM4E | |
| SCHEMBL18385086 | 0.69 | ILK (0.53) | KDM4ERAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040266842-A1 | Thiazolyl substituted triazoles as alk5 inhibitors | GASTER LARAMIE MARY | 2004-12-30 | — | — | US | claimed |
| EP-1444227-A1 | THIAZOLYL SUBSTITUTED TRIAZOLES AS ALK5 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-08-11 | — | — | EP | claimed |
| WO-2003042207-A1 | THIAZOLYL SUBSTITUTED TRIAZOLES AS ALK5 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-22 | — | — | WO | claimed |
| US-20040266842-A1 | Thiazolyl substituted triazoles as alk5 inhibitors | GASTER LARAMIE MARY | 2004-12-30 | — | — | US | disclosed |
| EP-1444227-A1 | THIAZOLYL SUBSTITUTED TRIAZOLES AS ALK5 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-08-11 | — | — | EP | disclosed |
| WO-2003042207-A1 | THIAZOLYL SUBSTITUTED TRIAZOLES AS ALK5 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-05-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040266842-A1 | Thiazolyl substituted triazoles as alk5 inhibitors | CBR3, CBR1, ALK | MEN1 4300/4885KMT2A 3175/4885GABRA1 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.