Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 3/20 | 0.36 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.36 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.36 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713338 | 0.80 | L3MBTL1 (0.38) | ALDH1A1KDM4EPOLBSMN1; SMN2HTT | |
| SCHEMBL7946318 | 0.79 | HRH2 (0.45) | ALOX15HRH2HRH1SMN1; SMN2 | |
| SCHEMBL3664525 | 0.79 | L3MBTL1 (0.40) | ALDH1A1KDM4EPOLBSMN1; SMN2HTT | |
| SCHEMBL4634418 | 0.77 | HRH2 (0.38) | HRH2HRH1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8815940 | 0.77 | ALDH1A1 (0.41) | ALDH1A1KDM4EPOLBCYP2C19SMN1; SMN2 | |
| SCHEMBL3636033 | 0.76 | CA2 (0.35) | GNAI3GNAO1GNAI1ALDH1A1POLB | |
| SCHEMBL4050766 | 0.75 | ALDH1A1 (0.53) | ALOX15HRH2HRH1ALDH1A1KDM4E | |
| SCHEMBL4440022 | 0.75 | DPP4 (0.39) | ALDH1A1POLBSMN1; SMN2HTTPLA2G7 | |
| SCHEMBL5595638 | 0.75 | ALDH1A1 (0.33) | ALDH1A1POLBSMN1; SMN2HTTABHD6 | |
| SCHEMBL20857025 | 0.74 | CYP2C19 (0.48) | ALOX15HRH2HRH1GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1453501-A1 | N- ARYL-N'-ARYLCYCLOALKYL-UREA DERIVATIVES AS MCH ANTAGONISTS FOR THE TREATMENT OF OBESITY | SCHERING CORPORATION (US) | 2004-09-08 | — | — | EP | disclosed |
| WO-2003047568-A1 | N-ARYL-N'-ARYLCYCLOALKYL-UREA DERIVATIVES AS MCH ANTAGONISTS FOR THE TREATMENT OF OBESITY | SCHERING CORPORATION (US) | 2003-06-12 | — | — | WO | disclosed |