Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5713338 | 0.98 | L3MBTL1 (0.38) | L3MBTL1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL3636033 | 0.83 | CA2 (0.35) | ALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL5595638 | 0.82 | ALDH1A1 (0.33) | MEN1KMT2AALDH1A1POLBHTT | |
| SCHEMBL4440022 | 0.82 | DPP4 (0.39) | L3MBTL1TDP1ALDH1A1POLBCHRM1 | |
| SCHEMBL7488600 | 0.82 | PRMT5 (0.38) | MEN1KMT2AALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL6880128 | 0.81 | DPP8 (0.35) | ALDH1A1POLBHTTSMN1; SMN2 | |
| SCHEMBL8815940 | 0.81 | ALDH1A1 (0.41) | L3MBTL1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL17159867 | 0.80 | L3MBTL1 (0.40) | L3MBTL1MEN1KMT2ATDP1ALDH1A1 | |
| SCHEMBL3999753 | 0.80 | POLB (0.33) | POLB | |
| SCHEMBL6622774 | 0.79 | ALOX15 (0.37) | ALDH1A1POLBHTTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229374-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009074789-A1 | AMIDO-THIOPHENE COMPOUNDS AND THEIR USE AS 11-BETA-HSD1 INHIBITORS | THE UNIVERSITY OF EDINBURGH (GB) | 2009-06-18 | — | — | WO | disclosed |