Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | STAT1 | P42224 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 15/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 15/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 15/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 15/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4045958 | 0.82 | MAPK13 (0.65) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6204219 | 0.80 | MAPK13 (0.50) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6768279 | 0.80 | CCNA2 (0.51) | ALDH1A1LMNASMN1; SMN2MAPK13MAPK12 | |
| SCHEMBL2410945 | 0.79 | RAB9A (0.56) | KDM4EMITFALDH1A1LMNASTAT3 | |
| SCHEMBL4849176 | 0.78 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4854229 | 0.78 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6774532 | 0.78 | MAPT (0.54) | MAPK14 | |
| SCHEMBL6624106 | 0.77 | MAPK14 (0.62) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6690362 | 0.75 | GPR119 (0.45) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6660862 | 0.75 | GPR119 (0.43) | MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1485167-A1 | 1,2-DIHYDROPYRAZOL-3-ONES AS CYTOKINE MEDIATORS | The Procter & Gamble Company (US) | 2004-12-15 | — | — | EP | disclosed |
| US-6677337-B2 | RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, INFLAMMATORY BOWEL DISEASE, CACHEXIA, SEPTIC SHOCK, CARDIOVASCULAR AND RESPIRATORY SYSTEM DISORDERS | THE PROCTER & GAMBLE COMPANY | 2004-01-13 | — | — | US | disclosed |
| US-20030225082-A1 | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines | PROCTER & GAMBLE COMPANY, THE | 2003-12-04 | — | — | US | disclosed |
| WO-2003080184-A1 | 1,2-DIHYDROPYRAZOL-3-ONES AS CYTOKINE MEDIATORS | THE PROCTER & GAMBLE COMPANY (US) | 2003-10-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225082-A1 | 1,2-dihydropyrazol-3-ones which controls inflammatory cytokines | IL1B, IL1A, IL1R1 | KDM4E 3915/4885MITF 4370/4885ALDH1A1 122/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.