Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 19/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 19/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 19/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 19/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4858007 | 0.86 | MAPK13 (0.47) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4849176 | 0.86 | MAPK13 (0.46) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL14294638 | 0.83 | MAPK14 (0.46) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4859070 | 0.83 | MAPK14 (0.46) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4045958 | 0.83 | MAPK13 (0.65) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6204219 | 0.81 | MAPK13 (0.50) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6622969 | 0.78 | KDM4E (0.43) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4861369 | 0.77 | MAPK14 (0.77) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL4861384 | 0.77 | MAPK14 (0.77) | MAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL6202797 | 0.77 | MAPK13 (0.49) | MAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7368455-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-05-06 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| US-7326714-B2 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2008-02-05 | — | — | US | disclosed |
| EP-1427728-B1 | 6,7-DIHYDRO-5H-PYRAZOLO 1,2-A PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY cYTOKINES | PROCTER & GAMBLE (US) | 2007-03-07 | — | — | EP | disclosed |
| US-7087615-B2 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | THE PROCTER & GAMBLE COMPANY (US) | 2006-08-08 | — | — | US | disclosed |
| US-20050282844-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2005-12-22 | — | — | US | disclosed |
| US-6960593-B2 | 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2005-11-01 | — | — | US | disclosed |
| US-20050148610-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY (US) | 2005-07-07 | — | — | US | disclosed |
| EP-1539761-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A] PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2005-06-15 | — | — | EP | disclosed |
| US-6849627-B2 | Including interleukin-1 and Tumor Necrosis Factor; treating rheumatoid arthritis, osteoarthritis, inflammatory bowel disease, septic shock, cardiopulmonary dysfunction, acute respiratory disease, and cachexia | THE PROCTER & GAMBLE COMPANY (US) | 2005-02-01 | — | — | US | disclosed |
| EP-1427728-A1 | 6,7-DIHYDRO-5H-PYRAZOLO 1,2-A PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY cYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2004-06-16 | — | — | EP | disclosed |
| US-20040087639-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | THE PROCTER & GAMBLE COMPANY | 2004-05-06 | — | — | US | disclosed |
| US-6730668-B2 | PREVENTING EXTRACELLULAR RELEASE | THE PROCTER & GAMBLE COMPANY | 2004-05-04 | — | — | US | disclosed |
| WO-2004026878-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-a]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |
| US-20040058944-A1 | 6,7-Dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones whinch control inflammatory cytokines | PROCTER & GAMBLE COMPANY, THE | 2004-03-25 | — | — | US | disclosed |
| US-20040038971-A1 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2004-02-26 | — | — | US | disclosed |
| US-20030134867-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | THE PROCTER & GAMBLE COMPANY | 2003-07-17 | — | — | US | disclosed |
| WO-2003024971-A1 | 6,7-DIHYDRO-5H-PYRAZOLO[1,2-A]PYRAZOL-1-ONES WHICH CONTROL INFLAMMATORY CYTOKINES | THE PROCTER & GAMBLE COMPANY (US) | 2003-03-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040087639-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which provide analgesia | OPRK1, OPRD1, IL1B | MAPK13 1562/4885MAPK12 1892/4885MAPK11 619/4885 |
| US-20050148610-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL6, IL1A, IL1B | MAPK13 2874/4885MAPK12 2866/4885MAPK11 3056/4885 |
| US-20040038971-A1 | 6,7-dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL1B, IL1A, IL6 | MAPK13 2320/4885MAPK12 1929/4885MAPK11 2212/4885 |
| US-20040058944-A1 | 6,7-Dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones whinch control inflammatory cytokines | IL6, IL1A, IL1B | MAPK13 3329/4885MAPK12 2305/4885MAPK11 3000/4885 |
| US-20030134867-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL1B, IL6, IL1A | MAPK13 1317/4885MAPK12 1789/4885MAPK11 552/4885 |
| US-20050282844-A1 | 6,7-Dihydro-5H-pyrazolo[1,2-a]pyrazol-1-ones which control inflammatory cytokines | IL1A, IL6, IL1B | MAPK13 2307/4885MAPK12 1427/4885MAPK11 1786/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.