Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRACR2A | Q9BSW2 | 5/20 | 0.46 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6614591 | 0.90 | P2RY14 (0.42) | CRACR2ANAMPTROCK2KDM4EHDAC1 | |
| SCHEMBL6608110 | 0.87 | CRACR2A (0.44) | CRACR2ANAMPTKDM4ELMNATDP1 | |
| SCHEMBL6651951 | 0.87 | P2RY14 (0.41) | CRACR2ANAMPTLMNAHDAC1MAPT | |
| SCHEMBL6618535 | 0.87 | CNR1 (0.41) | CRACR2AKDM4ECNR1SMN1; SMN2 | |
| SCHEMBL6620569 | 0.87 | CNR1 (0.41) | CRACR2AROCK2KDM4ELMNATDP1 | |
| SCHEMBL6618083 | 0.87 | NAMPT (0.46) | CRACR2ANAMPTROCK2HDAC1MAPT | |
| SCHEMBL6615869 | 0.87 | NAMPT (0.41) | CRACR2ANAMPTROCK2HDAC1HTT | |
| SCHEMBL6619833 | 0.86 | TRPV1 (0.43) | NAMPT | |
| SCHEMBL6651075 | 0.86 | KMT2A (0.39) | NAMPTKDM4ELMNATDP1HTT | |
| SCHEMBL6622866 | 0.85 | KDM4E (0.40) | KDM4ELMNATDP1CNR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1458379-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | Pharmacia Italia S.p.A. (IT) | 2004-09-22 | — | — | EP | claimed |
| WO-2003051358-A1 | HYDROXYPHENYL-PYRAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PHARMACIA ITALIA SPA (IT) | 2003-06-26 | — | — | WO | claimed |