SCHEMBL6624503

SCHEMBL6624503

CC1(c2ccc(N3CCOCC3)cc2)NC(=S)N(c2ccc3c(c2)OCO3)C1=O

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.54
MAPK1 P28482 1/20 0.54
POLB P06746 1/20 0.45
HSD17B10 Q99714 1/20 0.45
ALDH1A1 P00352 4/20 0.44
GAA P10253 3/20 0.44
CMA1 P23946 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
DYRK3 O43781 1/20 0.41
PIM1 P11309 1/20 0.41
CSNK2A2 P19784 1/20 0.41
CSNK2B P67870 1/20 0.41
CSNK2A1 P68400 1/20 0.41
DYRK1A Q13627 1/20 0.41
CSNK2A3 Q8NEV1 1/20 0.41
DYRK2 Q92630 1/20 0.41
DYRK1B Q9Y463 1/20 0.41
FLT3 P36888 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6626671 0.83 RAD51 (0.47) MAPTMAPK1POLBALDH1A1GAA
SCHEMBL6625012 0.82 CNR1 (0.46) MAPTMAPK1ALDH1A1GAASMN1; SMN2
SCHEMBL6625944 0.82 ALDH1A1 (0.48) MAPTMAPK1HSD17B10ALDH1A1GAA
SCHEMBL6625470 0.82 MAPT (0.52) MAPTMAPK1POLBHSD17B10ALDH1A1
SCHEMBL6170632 0.82 ALDH1A1 (0.46) MAPTPOLBHSD17B10ALDH1A1GAA
SCHEMBL6624454 0.81 HTT (0.42) MAPTMAPK1POLBALDH1A1GAA
SCHEMBL6628115 0.81 CNR1 (0.49) MAPTMAPK1ALDH1A1NPC1RAB9A
SCHEMBL6623977 0.81 MGAT2 (0.40) MAPTMAPK1ALDH1A1GAASMN1; SMN2
SCHEMBL6624722 0.81 HTR1A (0.47) MAPTMAPK1POLBALDH1A1GAA
SCHEMBL6628598 0.81 MAPT (0.51) MAPTMAPK1POLBALDH1A1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1373219-A1 THIOHYDANTOINS AND USE THEREOF FOR TREATING DIABETES LABORATOIRES FOURNIER S.A. (FR) 2004-01-02 EP disclosed
WO-2002081453-A1 THIOHYDANTOINS AND USE THEREOF FOR TREATING DIABETES LABORATOIRES FOURNIER SA (FR) 2002-10-17 WO disclosed