Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 4/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30790437 | 0.86 | CLK4 (0.40) | CLK4ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL4186953 | 0.78 | ALDH1A1 (0.34) | CLK4ALDH1A1MAPTHTTKMT2A | |
| SCHEMBL28288771 | 0.76 | EGFR (0.32) | EGFR | |
| SCHEMBL4192166 | 0.74 | MAPT (0.52) | MEN1MAPTHTTKMT2AADRA2A | |
| SCHEMBL20482144 | 0.72 | ADRA2A (0.33) | ADRA2AADRA2CADRA1DADRA1AADRA1B | |
| SCHEMBL4341944 | 0.72 | HTR1A (0.33) | CYP3A4CYP2C19 | |
| SCHEMBL7249060 | 0.70 | RHOA (0.32) | ALDH1A1MAPTHTTADRA2AADRA2C | |
| SCHEMBL28412569 | 0.69 | CYP1A2 (0.37) | CLK4ALDH1A1EGFRCYP1A2CYP3A4 | |
| SCHEMBL6796757 | 0.68 | ADRA2A (0.35) | ALDH1A1MEN1MAPTHTTKMT2A | |
| SCHEMBL12610928 | 0.67 | EGFR (0.44) | ALDH1A1MEN1MAPTKMT2APIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3590941-B1 | UREA-SUBSTITUTED AROMATIC RING-LINKED DIOXANE-QUINAZOLINE AND -LINKED DIOXANE-QUINOLINE COMPOUNDS, PREPARATION METHOD THEREFOR AND USE THEREOF | BEIJING SCITECH MQ PHARMACEUTICALS LTD (CN) | 2023-11-22 | — | — | EP | disclosed |
| CN-109776551-B | Process for preparing dioxanoquinazoline derivatives | 北京工业大学 | 2020-11-03 | — | — | CN | disclosed |
| CN-109776551-A | Dioxanes and quinazoline derivant preparation method | 北京工业大学 | 2019-05-21 | — | — | CN | disclosed |
| EP-1381612-A1 | ANTIDEPRESSANT AZA-HETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINAZOLINE | Wyeth (US) | 2004-01-21 | — | — | EP | disclosed |
| EP-1381612-A1 | ANTIDEPRESSANT AZA-HETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINAZOLINE | Wyeth (US) | 2004-01-21 | — | — | EP | disclosed |
| US-6656947-B2 | For therapy of depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse | WYETH | 2003-12-02 | — | — | US | disclosed |
| US-20020183341-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline | WYETH (US) | 2002-12-05 | — | — | US | disclosed |
| WO-2002088129-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINAZOLINE | WYETH (US) | 2002-11-07 | — | — | WO | disclosed |
| WO-2002088129-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF 2,3-DIHYDRO-1,4-DIOXINO[2,3-F]QUINAZOLINE | WYETH (US) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183341-A1 | Antidepressant azaheterocyclylmethyl derivatives of 2,3-dihydro-1,4-dioxino[2,3-f]quinazoline | OPRD1, OPRK1, HTR2C | CLK4 4106/4885ALDH1A1 171/4885MEN1 4505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.