Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HTR1D | P28221 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | THPO | P40225 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7205820 | 0.84 | SLC6A4 (0.53) | HTR2CCYP1A2CYP3A4ALDH1A1HTR6 | |
| SCHEMBL6841621 | 0.77 | HTR1D (0.49) | HTR2CCYP1A2CYP3A4ALDH1A1HTR6 | |
| SCHEMBL6497949 | 0.76 | TDO2 (0.46) | SLC6A4 | |
| SCHEMBL3836149 | 0.75 | HTR6 (0.67) | HTR2CCYP1A2CYP3A4ALDH1A1HTR6 | |
| SCHEMBL5435851 | 0.74 | HTR2C (0.56) | HTR2CCYP1A2CYP3A4ALDH1A1HTR6 | |
| SCHEMBL7328255 | 0.74 | TDO2 (0.47) | HTR2CCYP1A2CYP3A4ALDH1A1HTR6 | |
| SCHEMBL8798676 | 0.73 | HTR2B (0.40) | HTR2CALDH1A1HTR6KDM4EMEN1 | |
| SCHEMBL5367487 | 0.69 | SLC6A4 (0.76) | HTR6KDM4EHSD17B10LMNAHTR1A | |
| SCHEMBL6492415 | 0.69 | AR (0.42) | HTR1DHTR2A | |
| SCHEMBL13302269 | 0.68 | DYRK1A (0.55) | HTR2CCYP1A2CYP3A4ALDH1A1HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1377580-A2 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2004-01-07 | — | — | EP | disclosed |
| WO-2002060871-A2 | BENZENESULFONIC ACID INDOL-5-YL ESTERS AS ANTAGONISTS OF THE 5-HT6 RECEPTOR | ELI LILLY AND COMPANY (US) | 2002-08-08 | — | — | WO | disclosed |