Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 4/20 | 0.53 |
| ▸ | HTR6 | P50406 | 4/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625901 | 0.84 | HTR2C (0.41) | SLC6A4HTR6HTR1AHTR2AALDH1A1 | |
| SCHEMBL18129649 | 0.76 | DYRK1A (0.49) | SLC6A4HTR2ACYP3A4HTR2CPDPK1 | |
| SCHEMBL18136456 | 0.76 | DYRK1A (0.49) | SLC6A4HTR2ACYP3A4HTR2CPDPK1 | |
| SCHEMBL6497949 | 0.76 | TDO2 (0.46) | SLC6A4GPR84 | |
| SCHEMBL7460028 | 0.75 | HTR6 (0.67) | SLC6A4HTR6HTR7DRD2HTR2A | |
| SCHEMBL6841621 | 0.74 | HTR1D (0.49) | SLC6A4HTR6HTR1ADRD2HTR2A | |
| Water SCHEMBL10867618 | 0.74 | HTR6 (0.70) | SLC6A4HTR6HTR7DRD2HTR2A | |
| SCHEMBL5429556 | 0.74 | GPR84 (0.62) | SLC6A4HTR6HTR1AHTR7DRD2 | |
| SCHEMBL7328255 | 0.74 | TDO2 (0.47) | HTR6ALDH1A1MAPTCYP1A2KDM4E | |
| SCHEMBL12127324 | 0.70 | SLC6A4 (0.60) | SLC6A4HTR6HTR1AHTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6608079-B1 | Activating serotonin-1F receptors, inhibiting neuronal protein extravasation, treating migraine | ELI LILLY AND COMPANY | 2003-08-19 | — | — | US | disclosed |
| WO-2000034266-A1 | INDOLE DERIVATIVES AND THEIR USE AS 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 2000-06-15 | — | — | WO | disclosed |