Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6631274 | 1.00 | LMNA (0.37) | LMNAKDM4EALDH1A1HPGDRECQL | |
| SCHEMBL6632445 | 0.96 | LMNA (0.37) | LMNAKDM4EALDH1A1HPGDRECQL | |
| SCHEMBL6627233 | 0.96 | LMNA (0.37) | LMNAKDM4EALDH1A1HPGDRECQL | |
| SCHEMBL6676539 | 0.86 | LMNA (0.38) | LMNAKDM4EALDH1A1HPGDRECQL | |
| SCHEMBL6674662 | 0.86 | LMNA (0.38) | LMNAKDM4EALDH1A1HPGDRECQL | |
| SCHEMBL5957072 | 0.80 | PRMT5 (0.36) | LMNAALDH1A1CYP3A4MAPTCYP2C9 | |
| SCHEMBL21198804 | 0.77 | NPC1 (0.48) | LMNAALDH1A1HPGDSMN1; SMN2AR | |
| SCHEMBL21213918 | 0.77 | NPC1 (0.48) | LMNAALDH1A1HPGDSMN1; SMN2AR | |
| SCHEMBL5103595 | 0.74 | RAB9A (0.42) | LMNAALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL5112302 | 0.73 | RAB9A (0.41) | LMNAALDH1A1MAPTSMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381613-B1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF OXAHETEROCYCLE-FUSED-(1,4)-BENZODIOXANS | WYETH CORP (US) | 2004-10-13 | — | — | EP | disclosed |
| US-6706736-B2 | AMINES SUCH AS 3-(1-((8-METHYL-2,3-DIHYDROFURO(2,3-F)(1,4) BENZODIOXIN-2-YL)METHYL)-1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE, ADMINISTERED AS SEROTONIN REUPTAKE INHIBITORS OR ANXIOLYTIC AGENTS | WYETH | 2004-03-16 | — | — | US | disclosed |
| EP-1381613-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF OXAHETEROCYCLE-FUSED- 1,4]-BENZODIOXANS | Wyeth (US) | 2004-01-21 | — | — | EP | disclosed |
| US-20030162805-A1 | Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans | WYETH (US) | 2003-08-28 | — | — | US | disclosed |
| US-6552049-B2 | For therapy of depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse | WYETH | 2003-04-22 | — | — | US | disclosed |
| US-20020183353-A1 | Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans | WYETH (US) | 2002-12-05 | — | — | US | disclosed |
| WO-2002088135-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF OXAHETEROCYCLE-FUSED-[1,4]-BENZODIOXANS | WYETH (US) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162805-A1 | Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans | OPRD1, OPRM1, OPRK1 | LMNA 4362/4885KDM4E 1644/4885ALDH1A1 77/4885 |
| US-20020183353-A1 | Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans | OPRD1, OPRM1, OPRK1 | LMNA 4325/4885KDM4E 1815/4885ALDH1A1 109/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.