Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 10/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.45 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6626307 | 0.86 | MAPT (0.52) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6626132 | 0.86 | ADAM17 (0.42) | MAPTALDH1A1SLC6A9SLC6A5MEN1 | |
| SCHEMBL6629939 | 0.83 | MAPT (0.50) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6668688 | 0.81 | MAPT (0.49) | LMNAMAPTALDH1A1MAPK1SLC6A9 | |
| SCHEMBL6625449 | 0.80 | MAPT (0.47) | MAPTALDH1A1MAPK1MEN1KMT2A | |
| SCHEMBL6625004 | 0.77 | GSK3B (0.45) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL6697526 | 0.76 | MAPT (0.52) | LMNAMAPTALDH1A1MAPK1SLC6A9 | |
| SCHEMBL12643176 | 0.75 | MAPT (0.74) | LMNAMAPTALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL6626698 | 0.75 | KMT2A (0.43) | LMNAMAPTALDH1A1MAPK1MEN1 | |
| SCHEMBL6626057 | 0.75 | MAPT (0.48) | LMNAMAPTALDH1A1MAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1373219-A1 | THIOHYDANTOINS AND USE THEREOF FOR TREATING DIABETES | LABORATOIRES FOURNIER S.A. (FR) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002081453-A1 | THIOHYDANTOINS AND USE THEREOF FOR TREATING DIABETES | LABORATOIRES FOURNIER SA (FR) | 2002-10-17 | — | — | WO | disclosed |