Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.58 |
| ▸ | DRD4 | P21917 | 2/20 | 0.58 |
| ▸ | DRD3 | P35462 | 2/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629303 | 1.00 | DRD2 (0.58) | DRD2DRD4DRD3CYP3A4CHRNB4 | |
| SCHEMBL9205750 | 0.85 | DRD3 (0.57) | DRD2DRD4DRD3CYP3A4CHRNB4 | |
| SCHEMBL9205435 | 0.85 | DRD3 (0.57) | DRD2DRD4DRD3CYP3A4CHRNB4 | |
| SCHEMBL9206686 | 0.85 | DRD3 (0.57) | DRD2DRD4DRD3CYP3A4CHRNB4 | |
| Hydrochloric Acid SCHEMBL7816927 | 0.83 | DRD3 (0.56) | DRD2DRD4DRD3CYP3A4CHRNB4 | |
| Hydrochloric Acid SCHEMBL7831882 | 0.83 | DRD3 (0.56) | DRD2DRD4DRD3CYP3A4CHRNB4 | |
| SCHEMBL3586040 | 0.81 | CHRNB4 (0.46) | DRD2DRD4DRD3CHRNB4CHRNA3 | |
| SCHEMBL1021536 | 0.81 | CA2 (0.51) | DRD2DRD4DRD3SMN1; SMN2 | |
| SCHEMBL6984001 | 0.81 | CA2 (0.58) | DRD2DRD4DRD3HSD17B10 | |
| SCHEMBL6984007 | 0.81 | CA2 (0.58) | DRD2DRD4DRD3HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1381613-B1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF OXAHETEROCYCLE-FUSED-(1,4)-BENZODIOXANS | WYETH CORP (US) | 2004-10-13 | — | — | EP | disclosed |
| US-6706736-B2 | AMINES SUCH AS 3-(1-((8-METHYL-2,3-DIHYDROFURO(2,3-F)(1,4) BENZODIOXIN-2-YL)METHYL)-1,2,3,6-TETRAHYDRO-4-PYRIDINYL)-1H-INDOLE, ADMINISTERED AS SEROTONIN REUPTAKE INHIBITORS OR ANXIOLYTIC AGENTS | WYETH | 2004-03-16 | — | — | US | disclosed |
| EP-1381613-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF OXAHETEROCYCLE-FUSED- 1,4]-BENZODIOXANS | Wyeth (US) | 2004-01-21 | — | — | EP | disclosed |
| US-20030162805-A1 | Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans | WYETH (US) | 2003-08-28 | — | — | US | disclosed |
| US-6552049-B2 | For therapy of depression, obsessive compulsive disorder, panic attacks, generalized anxiety disorder, social anxiety disorder, sexual dysfunction, eating disorders, obesity, addictive disorders caused by ethanol or cocaine abuse | WYETH | 2003-04-22 | — | — | US | disclosed |
| US-20020183353-A1 | Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans | WYETH (US) | 2002-12-05 | — | — | US | disclosed |
| WO-2002088135-A1 | ANTIDEPRESSANT AZAHETEROCYCLYLMETHYL DERIVATIVES OF OXAHETEROCYCLE-FUSED-[1,4]-BENZODIOXANS | WYETH (US) | 2002-11-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162805-A1 | Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans | OPRD1, OPRM1, OPRK1 | DRD2 10/4885DRD4 22/4885DRD3 19/4885 |
| US-20020183353-A1 | Antidepressant azaheterocyclylmethyl derivatives of oxaheterocycle-fused-[1,4]-benzodioxans | OPRD1, OPRM1, OPRK1 | DRD2 17/4885DRD4 35/4885DRD3 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.