Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MMP1 | P03956 | 5/20 | 0.44 |
| ▸ | MMP13 | P45452 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 3/20 | 0.44 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.44 |
| ▸ | TFPI2 | P48307 | 4/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GMNN | O75496 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4654488 | 0.88 | MMP1 (0.47) | MMP1MMP13MMP8MMP2MMP3 | |
| SCHEMBL8182692 | 0.81 | CA1 (0.38) | LMNASMN1; SMN2ALDH1A1MMP1MMP13 | |
| SCHEMBL8596180 | 0.79 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1MMP1MMP13 | |
| SCHEMBL8596522 | 0.71 | MMP1 (0.47) | LMNASMN1; SMN2ALDH1A1MMP1MMP13 | |
| SCHEMBL7763707 | 0.66 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1MMP1MMP13 | |
| SCHEMBL6515525 | 0.63 | SOS1 (1.00) | LMNASMN1; SMN2ALDH1A1SOS1CA12 | |
| SCHEMBL1133806 | 0.63 | SOS1 (0.64) | LMNASMN1; SMN2ALDH1A1MMP1MMP13 | |
| SCHEMBL6123058 | 0.63 | HTT (0.81) | LMNASMN1; SMN2ALDH1A1MMP1MMP13 | |
| SCHEMBL17559302 | 0.63 | HTT (0.81) | LMNASMN1; SMN2ALDH1A1MMP1MMP13 | |
| SCHEMBL146566 | 0.63 | HTT (0.81) | LMNASMN1; SMN2ALDH1A1MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0950059-B1 | CYCLIC SULFONE DERIVATIVES | PFIZER (US) | 2004-08-04 | — | — | EP | disclosed |
| US-6077864-A | USEFUL IN THE TREATMENT OF ARTHRITIS, CANCER, TISSUE ULCERATION, MACULAR DEGENERATION, RESTENOSIS, PERIODONTAL DISEASE, EPIDERMOLYSIS BULLOSA, SCLERITIS | PFIZER INC. (US) | 2000-06-20 | — | — | US | disclosed |
| EP-0950059-A1 | CYCLIC SULFONE DERIVATIVES | PFIZER INC. (US) | 1999-10-20 | — | — | EP | disclosed |
| WO-1998030566-A1 | CYCLIC SULFONE DERIVATIVES | PFIZER INC. (US) | 1998-07-16 | — | — | WO | disclosed |