Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MMP2 | P08253 | 10/20 | 0.44 |
| ▸ | MMP9 | P14780 | 9/20 | 0.44 |
| ▸ | MMP14 | P50281 | 8/20 | 0.44 |
| ▸ | MMP1 | P03956 | 6/20 | 0.44 |
| ▸ | MMP3 | P08254 | 6/20 | 0.44 |
| ▸ | MMP7 | P09237 | 3/20 | 0.44 |
| ▸ | MMP8 | P22894 | 2/20 | 0.44 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.44 |
| ▸ | MMP13 | P45452 | 10/20 | 0.43 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.39 |
| ▸ | FNTB | P49356 | 1/20 | 0.39 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7758754 | 0.91 | MMP1 (0.46) | LMNASMN1; SMN2ALDH1A1MMP2MMP9 | |
| SCHEMBL7347615 | 0.86 | MMP2 (0.43) | LMNASMN1; SMN2ALDH1A1MMP2MMP9 | |
| SCHEMBL14843811 | 0.78 | CYP1A2 (0.39) | SMN1; SMN2ALDH1A1MMP2CA12CA1 | |
| SCHEMBL21358891 | 0.69 | MAPT (0.37) | SMN1; SMN2ALDH1A1CA12CA1CA2 | |
| SCHEMBL8596180 | 0.68 | LMNA (0.49) | LMNASMN1; SMN2ALDH1A1MMP2MMP9 | |
| SCHEMBL1529244 | 0.66 | LMNA (0.48) | LMNASMN1; SMN2MMP2MMP9MMP14 | |
| SCHEMBL6629126 | 0.66 | LMNA (0.47) | LMNASMN1; SMN2ALDH1A1MMP2MMP9 | |
| SCHEMBL27388988 | 0.65 | CA1 (0.39) | LMNAMMP2MMP9MMP14MMP1 | |
| SCHEMBL10582343 | 0.64 | HRH1 (0.43) | — | |
| SCHEMBL5286679 | 0.64 | HRH1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098662-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004892-A2 | COADMINISTRATION OF ACAT AND MMP INHIBITORS FOR THE TREATMENT OF ATHEROSCLEROTIC LESIONS | WARNER-LAMBERT COMPANY (US) | 2000-02-03 | — | — | WO | disclosed |