Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 7/20 | 0.46 |
| ▸ | MMP1 | P03956 | 5/20 | 0.46 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 7/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 6/20 | 0.41 |
| ▸ | MMP9 | P14780 | 5/20 | 0.41 |
| ▸ | MMP3 | P08254 | 2/20 | 0.41 |
| ▸ | MMP7 | P09237 | 2/20 | 0.41 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6629126 | 0.79 | LMNA (0.47) | LMNASMN1; SMN2ALDH1A1MMP13MMP1 | |
| SCHEMBL2000854 | 0.74 | ALDH1A1 (0.49) | SMN1; SMN2ALDH1A1POLBTDP1CA12 | |
| SCHEMBL8596522 | 0.73 | MMP1 (0.47) | LMNASMN1; SMN2ALDH1A1MMP13MMP1 | |
| SCHEMBL4654488 | 0.70 | MMP1 (0.47) | MMP13MMP1MMP8MMP2MMP14 | |
| SCHEMBL7763707 | 0.68 | LMNA (0.46) | LMNASMN1; SMN2ALDH1A1MMP13MMP1 | |
| SCHEMBL13475185 | 0.66 | ALDH1A1 (0.42) | LMNASMN1; SMN2ALDH1A1MMP2HTT | |
| SCHEMBL1133806 | 0.65 | SOS1 (0.64) | LMNASMN1; SMN2ALDH1A1MMP13MMP1 | |
| SCHEMBL6123058 | 0.65 | HTT (0.81) | LMNASMN1; SMN2ALDH1A1MMP13MMP1 | |
| SCHEMBL146566 | 0.65 | HTT (0.81) | LMNASMN1; SMN2ALDH1A1MMP13MMP1 | |
| SCHEMBL17559302 | 0.65 | HTT (0.81) | LMNASMN1; SMN2ALDH1A1MMP13MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0818442-A2 | Cyclic sulphone derivatives as inhibitors of metalloproteinases and of the production of tumour necrosis factor | PFIZER INC. (US) | 1998-01-14 | — | — | EP | disclosed |