Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP2 | Q13822 | 7/20 | 0.51 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.47 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.42 |
| ▸ | DRD4 | P21917 | 4/20 | 0.42 |
| ▸ | DRD3 | P35462 | 4/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 1/20 | 0.42 |
| ▸ | BDKRB2 | P30411 | 1/20 | 0.39 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.38 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 2/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP13 | P45452 | 2/20 | 0.38 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6632197 | 0.86 | ENPP2 (0.49) | ENPP2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5950413 | 0.82 | ITGB3 (0.56) | ENPP2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5950765 | 0.81 | ENPP2 (0.50) | ENPP2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5801129 | 0.81 | ENPP2 (0.55) | ENPP2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5950185 | 0.79 | ITGB3 (0.49) | ENPP2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5781916 | 0.76 | OPRM1 (0.52) | ENPP2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5799198 | 0.73 | OPRK1 (0.55) | OPRM1OPRD1OPRK1OPRL1DRD3 | |
| SCHEMBL5801972 | 0.71 | OPRM1 (0.51) | OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5950571 | 0.71 | ITGB3 (0.46) | ENPP2OPRM1OPRD1OPRK1OPRL1 | |
| SCHEMBL5802422 | 0.70 | NPC1L1 (0.49) | NPC1L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1489081-A1 | SPIRO DERIVATIVES AND ADHESION MOLECULE INHIBITORS COMPRISING THE SAME AS THE ACTIVE INGREDIENT | TORAY INDUSTRIES, INC. (JP) | 2004-12-22 | — | — | EP | disclosed |