⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL107198 | 0.73 | MAPT (0.61) | — | |
| SCHEMBL721735 | 0.73 | MAPT (0.47) | — | |
| SCHEMBL138489 | 0.73 | MAPT (0.61) | — | |
| SCHEMBL31175769 | 0.71 | MAPT (0.58) | — | |
| SCHEMBL135604 | 0.71 | MAPT (0.65) | — | |
| SCHEMBL27608463 | 0.71 | — | — | |
| SCHEMBL9966009 | 0.71 | MAPT (0.65) | — | |
| SCHEMBL8075904 | 0.69 | JUN (0.38) | — | |
| SCHEMBL6309146 | 0.69 | KIF11 (0.41) | — | |
| SCHEMBL14867 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102770182-B | Substituted isoquinolinones and quinazolinones | NOVARTIS AG (CH) | 2014-10-29 | — | — | CN | claimed |
| CN-101801949-B | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | claimed |
| CN-103917235-A | Kinase modulation and indications therefor | PLEXXIKON INC | 2014-07-09 | — | — | CN | claimed |
| CN-103402996-A | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2013-11-20 | — | — | CN | claimed |
| CN-101605787-B | Compounds that modulate c-fms and/or c-kit activity and uses thereof | PLEXXIKON INC | 2013-11-13 | — | — | CN | claimed |
| CN-101801949-A | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA NV | 2010-08-11 | — | — | CN | claimed |
| CN-104703623-A | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC | 2015-06-10 | — | — | CN | disclosed |
| CN-102770182-B | Substituted isoquinolinones and quinazolinones | NOVARTIS AG (CH) | 2014-10-29 | — | — | CN | disclosed |
| CN-101801949-B | Sulfonamides as TRPM8 modulators | JANSSEN PHARMACEUTICA NV | 2014-09-24 | — | — | CN | disclosed |
| CN-103917235-A | Kinase modulation and indications therefor | PLEXXIKON INC | 2014-07-09 | — | — | CN | disclosed |
| CN-103497188-A | Compounds modulating c-fms and/or c-kit activity and uses therefor | PLEXXIKON INC | 2014-01-08 | — | — | CN | disclosed |
| CN-103402996-A | Indole compounds or analogues thereof useful for the treatment of age-related macular degeneration (AMD) | NOVARTIS AG | 2013-11-20 | — | — | CN | disclosed |
| CN-101605787-B | Compounds that modulate c-fms and/or c-kit activity and uses thereof | PLEXXIKON INC | 2013-11-13 | — | — | CN | disclosed |
| EP-1417202-A2 | AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2004-05-12 | — | — | EP | disclosed |
| CN-1440385-A | Pyrrole derivatives for the treatment of AIDS | HOFFMANN LA ROCHE (CH) | 2003-09-03 | — | — | CN | disclosed |
| EP-1301481-A1 | PYRROLE DERIVATIVES FOR TREATING AIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-04-16 | — | — | EP | disclosed |
| US-20030069276-A1 | Amino piperidine derivatives | F.HOFFMANN-LA ROCHE AG (CH) | 2003-04-10 | — | — | US | disclosed |
| WO-2002079186-A2 | AMINOPIPERIDINE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | F. HOFFMANN-LA ROCHE AG (CH) | 2002-10-10 | — | — | WO | disclosed |
| US-20020032221-A1 | Pyrrole derivatives | ROCHE PRODUCTS LIMITED (GB) | 2002-03-14 | — | — | US | disclosed |
| WO-2002002524-A1 | PYRROLE DERIVATIVES FOR TREATING AIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-01-10 | — | — | WO | disclosed |