Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | CGAS | Q8N884 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | HBB | P68871 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27904897 | 0.80 | JUN (0.40) | JUNNFKB1CYP19A1CYP11B2MAPT | |
| SCHEMBL6299957 | 0.74 | MAPT (0.40) | JUNNFKB1CYP19A1CYP11B2MAPT | |
| SCHEMBL184701 | 0.72 | ALDH1A1 (0.41) | CYP19A1MAPTLMNASMN1; SMN2CYP1A2 | |
| SCHEMBL27763752 | 0.69 | MAPT (0.44) | CYP19A1CYP11B2MAPTLMNASMN1; SMN2 | |
| SCHEMBL6630607 | 0.69 | — | — | |
| SCHEMBL2927847 | 0.69 | — | — | |
| SCHEMBL107198 | 0.67 | MAPT (0.61) | JUNNFKB1CYP19A1CYP11B2MAPT | |
| SCHEMBL138489 | 0.67 | MAPT (0.61) | JUNNFKB1CYP19A1CYP11B2MAPT | |
| SCHEMBL721735 | 0.67 | MAPT (0.47) | JUNNFKB1CYP19A1CYP11B2MAPT | |
| SCHEMBL9537809 | 0.67 | CHRNB2 (0.35) | JUNNFKB1CYP19A1CYP11B2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6048880-A | THERAPY FOR CYTOKINE SENSITIVE DISEASES | PFIZER PHARAMACEUTICALS INC. (JP) | 2000-04-11 | — | — | US | disclosed |